Abstract

Introduction. Premenstrual syndrome (PMS) is a group of symptoms that many women get about a week or two before their period. Multiple sclerosis (MS) is an autoimmune-mediated disorder that affects the central nervous system (CNS). Aim. This study aimed to see the impact of premenstrual syndrome on multiple sclerosis symptoms. Methods. Forty women having MS and complained from PMS, aged 20-35 years, with BMI less than 30 kg/m2 were selected randomly from Health Insurance Authority in El-Dokki they were assessed during two periods (normal and premenstrual days). The MS symptoms was assessed through functional system scale; fatigue severity scale and numerical scale and also premenstrual symptoms are assessed by PMS tracker. Results. Multiple pairwise comparison tests revealed that there was significant increase in functional system score in premenstrual period (p=0.006), and also in fatigue severity scale in pre-menstrual period (p=0.0001). Numerical rating scale showed that there was significant increase in pain intensity (p=0.0001) which became more prominent in pre-menstrual period. Conclusion. Premenstrual syndrome has an effect on worsening the symptoms of multiple sclerosis.