Abstract

Among the many environmental and industrial factors that adversely affect the soil, the pollution with heavy metals and mycotoxins occupies a special place in livestock breeding. This study aimed to demonstrate methods of treating and pharmacological correction of a toxic state intensified by heavy metals and mycotoxins in cattle using native drug as mycotoxin-deactivating feed additive. A total of 20 highly productive Holstein cows aged 3-4 years were divided into 2 groups, based on clinical and biochemical parameters. The experimental group (n=10) fed a diet supplemented with 4% sorption complex and a drug based on Silybum marianum and ursodeoxycholic acid as a hepatoprotector named “Hepaton-vet”. The control group (n=10) was injected with a complex of sorbents (consisting of perlite, vermiculite, and polyphepan in equal proportions) at a dose of 4% of the daily intake of food, and the rest of the treatment was carried out with the help of daily infusion therapy. So in the feed samples, only the T-2 and Deoxynivalenol (DON) indicators exceeded the normal value by 1.66% and, 3%, respectively. Thus, the practical efficiency concerning T-2, aflatoxin and Deoxynivalenol were to 100%, 86%, 18%, respectively. Cadmium in compound feed was lower by 44%, in comparison with the maximum permissible concentration, followed by 53.3% in hay and 78% in silage. The amount of lead in compound feed and silage was 78%, and it was 35% in the hay. In conclusion, the use of a complex of sorbents, together with newly developed component “Hepaton-vet”, led to positive results, allowing for the identification of several effects that influenced the metabolic processes in the liver, which was confirmed by the results of morpho-biochemical blood tests and clinical diagnostics of the animals' condition.