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Effect of vitamin E on the prevention of peritoneal adhesions in sheep

(2018) Effect of vitamin E on the prevention of peritoneal adhesions in sheep. World's Veterinary Journal. pp. 90-94. ISSN 23224568 (ISSN)

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The objective of this study was to assess vitamin E solution on the prophylaxis of intraperitoneal adhesions in ovine uterine serosal damage model with bipolar diathermy. Therefore, 19 ewes underwent laparotomy for induction of adhesions, using a uterine serosal bipolar electrocauterization model. Cauterizations were performed on the right uterine horn serosa and right ovary. Ewes were randomly divided into three groups: control group (GCT, n=5), with no treatment following electrocoagulation, another group using local rinse of 20 mL of normal saline (GNS, n=8), and the last group using local rinse of 20 mL of vitamin E injection solution (GVE, n=6). On day 21 postoperative, animals underwent laparoscopy for scoring and comparison of intraperitoneal adhesion according to frequency and number. The number of adhesions was compared among groups using the Kruskal-Wallis test and Dunn’s post-hoc test. As results, the bipolar uterine serosal coagulation model triggered uterine adhesions in 74% (14/19) of the animals. Frequency of postoperative intraperitoneal adhesions was similar (P= 0.819) among groups (80% ewes of GCT, 62.5% of GNS and 83% of GVE). There was no significant difference between treatment groups, however, number of adhesions was lower in GVE and GNS groups than in control group (P= 0.032), showing that the addition of these kind of substances are better than not using any type of barrier to prevent the formation of intraperitoneal adhesions.

Item Type: Article
Keywords: Adhesions, Bipolar diathermy, Laparoscopy, Sheep, Uterus
Subjects: Q Science > Q Science (General)
S Agriculture > SF Animal culture
Divisions: World's Veterinary Journal (WVJ)
Page Range: pp. 90-94
Journal or Publication Title: World's Veterinary Journal
Journal Index: Scopus
Volume: 8
Number: 4
Publisher: Scienceline Publication, Ltd
ISSN: 23224568 (ISSN)
Depositing User: Dr. Alireza Sadeghi

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