Abstract

Nucleotides can improve intestinal health by modulating the local immune response and intestinal mucosa development in weaned piglets. This study was conducted to evaluate the growth performance of post weaned piglets and evaluated the economic analysis of nucleotides supplementation for 30 days. A total of 120 mixed breed piglets were selected at the weaning stage and were used in the experiment as control group vs. treatment 2 supplemented with nucleotide. Each treatment consisted of 60 heads with three replications with 20 heads per replication arranged in Complete Randomized Design. Results were analyzed through Pairwise T and LSD tests. In terms of growth performance, results showed that supplementation of nucleotide had significantly increased the average daily gain, feed conversion ratio and weight gain by 0.50, 1.20 and 15.02 kg, respectively. However, there was no significant difference in terms of the average daily feed intake. With regards to the economic analysis, total production input had no effect with or without nucleotide supplementation but surprisingly, it had a gross margin of Php 95,900 (Philippine peso money) which was 5 more as with those that have supplementation. As to the net income, supplementation of nucleotides increased about 40.7 in comparison to control. Furthermore, a peso of investment could have a return of about 18 cents (1050 Php) more returns with supplementation, which apparently had 0.11 cents leverage compared to control group (0.07 cents). In conclusion, nucleotide supplementation not only improved the growth performance of post-weaned piglets but also enhanced profitability, offering a significant return on investment for swine producers. This makes nucleotide supplementation a promising strategy for improving both animal health and economic outcomes in swine production. © The Author(s) 2025