CLINICOPATHOLOGICAL CHARACTERIZATION OF CUTANEOUS PAPILLOMATOSIS IN CATTLE FROM NEW VALLEY GOVERNORATE, EGYPT

AL GHAYTHAN, Ali Awadh and MARZOK, Mohamed and ELKHIDR, Rasha Yassin and SHOUSHA, Saad and SABER, Mahmoud and EL-SHERIF, Mohamed and HASSAN, Mahmoud (2026) CLINICOPATHOLOGICAL CHARACTERIZATION OF CUTANEOUS PAPILLOMATOSIS IN CATTLE FROM NEW VALLEY GOVERNORATE, EGYPT. Online Journal of Animal and Feed Research. 132 - 139. ISSN 22287701

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Abstract

Bovine papillomatosis is a contagious proliferative skin disease of cattle caused by bovine papillomaviruses (BPVs). It is characterized by exophytic, papillary, or cauliflower-like lesions affecting the skin or mucous membranes and occurs worldwide, particularly in young animals. Histopathology remains a reliable confirmatory diagnostic tool in field settings lacking molecular techniques. This descriptive observational field study included 50 cattle with lesions clinically consistent with cutaneous papillomatosis. Animals of both sexes, aged 9 months to 4 years, were evaluated for sex, age, lesion size, multiplicity, and anatomical distribution. Representative lesions were surgically excised, fixed in 10 neutral buffered formalin, processed by routine paraffin embedding, sectioned at 4μm, and stained with hematoxylin and eosin. Data are presented as counts and percentages, and the study followed STROBE guidelines. Most affected cattle were female (76.0) and aged 9-18 months (74.0). Lesions smaller than 10 cm³ predominated (78.0). Multiple lesions were more common than solitary ones, with three animals presenting up to 20 lesions each. A total of 211 lesion sites were recorded, with the highest frequency in the head and neck region (51.7), followed by the chest, abdomen, and withers (23.2). Histopathology revealed epidermal hyperplasia, hyperkeratosis, acanthosis, elongated rete pegs, papillary projections with fibrovascular cores, fibroblastic proliferation, and variable inflammatory infiltration, including occasional vascular thrombosis. This study showed that bovine cutaneous papillomatosis in this setting predominantly affects young cattle and shows a marked predilection for the head and neck. Histopathological features align with classical papillomatous and fibropapillomatous lesions, supporting their value as a practical diagnostic tool in field conditions. © 2026 The Authors. All right reserved.

Item Type:	Article
Keywords:	Cattle; Molecular typing; Mucous membranes; Papillomatosis; Skin
Subjects:	S Agriculture > SF Animal culture
Divisions:	Online Journal of Animal and Feed Research (OJAFR)
Page Range:	132 - 139
Journal or Publication Title:	Online Journal of Animal and Feed Research
Journal Index:	Scopus
Volume:	16
Number:	3
Publisher:	Scienceline Publications, Ltd
Identification Number:	https://doi.org/10.51227/ojafr.2026.16
ISSN:	22287701
Depositing User:	Dr. Saeid Chekani-Azar
URI:	https://eprints.science-line.com/id/eprint/1793

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