Effects of Choline-Rich Fermented Crescentia cujete on Blood Parameters, Superoxide Dismutase, and Cerebral Interleukin-6 in Rats after Induced Ischemic Stroke

Fiohana, Puput and Prakoso, Yos Adi and Widyarini, Sitarina and Hidayah, Jasir Hakim and Wahyuningtyas, Puput Ade and Susilo, Achmadi (2025) Effects of Choline-Rich Fermented Crescentia cujete on Blood Parameters, Superoxide Dismutase, and Cerebral Interleukin-6 in Rats after Induced Ischemic Stroke. World's Veterinary Journal. 845 - 853. ISSN 2322-4568

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Abstract

Ischaemic stroke is a major vascular disorder that profoundly impacts human health. Choline-rich fermented Crescentia cujete (Ch-RFCC) has emerged as a promising adjunctive therapy for ischemic stroke; however, its effects on hematological parameters, superoxide dismutase (SOD) activity, and interleukin-6 (IL-6) levels remain unexplored. The present study aimed to assess the impacts of Ch-RFCC on hematological parameters, SOD activity, and brain IL-6 levels in the rats' ischemic stroke model (ISM). A total of 40 three-month-old male rats, weighing 247.31 ± 4.95 g, were randomly assigned into four groups, including healthy rats with a skin incision as the control group (sham-operated, T1), ISM without treatment (T2), ISM treated with 496 mg/kg body weight of piracetam (T3), and ISM treated with 11.84 mg/kg body weight of Ch-RFCC (T4). Treatments using piracetam (T3) and Ch-RFCC (T4) were administered orally via gavage twice daily for 14 consecutive days. The current results demonstrated that Group T4 maintained haemoglobin and haematocrit levels, normalised the platelet-to-leucocyte ratio and neutrophil counts, reduced fibrinogen levels, elevated SOD activity, and enhanced IL-6 immunoreactivity compared to the untreated ISM group (T2). Furthermore, rats in Group T4 exhibited the least body weight loss compared to those in groups T2 and T3. These findings indicated that Ch-RFCC may alleviate ischemic stroke in rats by enhancing antioxidant defenses, modulating IL-6 expression, and preserving hematological homeostasis. © The Author(s) 2025. Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article�s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article�s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/.

Item Type:	Article
Keywords:	Choline-rich fermented Crescentia cujete; Hematology; Interleukin-6; Ischemic stroke; Superoxide dismutase
Subjects:	S Agriculture > SF Animal culture
Divisions:	World's Veterinary Journal (WVJ)
Page Range:	845 - 853
Journal or Publication Title:	World's Veterinary Journal
Journal Index:	Scopus
Volume:	15
Number:	4
Publisher:	Scienceline Publication
Identification Number:	https://doi.org/10.54203/scil.2025.wvj86
ISSN:	2322-4568
Depositing User:	Dr. Alireza Sadeghi
URI:	https://eprints.science-line.com/id/eprint/1667

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