Current vaccine candidate of toxoplasmosis

WOLDEGERIMA, Eden and GETACHEW, Fasika and MISGANAW, Meseret and MESFIN, Yohannes and BELETE, Debaka and SISAY, Tekeba and BERHANE, Nega (2024) Current vaccine candidate of toxoplasmosis. Journal of Life Science and Biomedicine. pp. 54-67. ISSN 2251-9939

Text JLSB 14(3) 54-67, 2024.pdf - Published Version Download (788kB)

Abstract

Toxoplasma gondii is an intracellular protozoan parasite belonging from the phylum Apicomplexa, known for causing toxoplasmosis. The disease has a global presence, affecting about one-third of the world’s population. The parasite infects various intermediate hosts, including humans and other warm-blooded mammals, with cats serving as the definitive hosts. Its life cycle is complex, featuring a sexual phase in the definitive host and an asexual phase in intermediate hosts. Toxoplasmosis can leads severe neurologic, ocular, and systemic diseases in neonates and immunocompromised individuals. In immunocompetent individuals, the infection is typically asymptomatic, forming dormant tissue cysts in immune-privileged sites such as the muscles and brain. During pregnancy, toxoplasmosis poses significant health risks, potentially causing severe birth defects or miscarriage, and a major concern for immunocompromised hosts. Current control measures are inadequate, highlighting the need for effective vaccines. The initial host defense against T. gondii occurs at the intestinal mucosa, where cytokines and chemokines released by intestinal epithelial cells facilitate the migration of inflammatory cells, including macrophages, neutrophils, and dendritic cells. Developing a vaccine that can enhance this mucosal immunity is crucial for preventing toxoplasmosis. Therefore, the development of vaccines against T.gondii is a promising alternative mechanism to prevent toxoplasmosis. This review aims to present the current status of vaccine candidates against Toxoplasma gondii.

Item Type:	Article
Keywords:	Vaccine, Candidate, Toxoplasmosis, Toxoplasma gondii
Subjects:	R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services S Agriculture > SF Animal culture
Divisions:	Journal of Life Sciences and Biomedicine (JLSB)
Page Range:	pp. 54-67
Journal or Publication Title:	Journal of Life Science and Biomedicine
Journal Index:	Not Index
Volume:	14
Number:	3
Publisher:	Scienceline Publication
Identification Number:	https://doi.org/10.54203/jlsb.2024.6
ISSN:	2251-9939
Depositing User:	Dr. Zohreh Yousefi
URI:	https://eprints.science-line.com/id/eprint/1293

Actions (login required)

View Item