The diagnostic accuracy of currently available laboratory tests compared to PCR test for COVID-19: a systematic review and meta-analysis

BIRHAN, Mastewal (2023) The diagnostic accuracy of currently available laboratory tests compared to PCR test for COVID-19: a systematic review and meta-analysis. Journal of Life Science and Biomedicine. pp. 1-11. ISSN 2251-9939

Text JLSB 13(1) 01-11, 2023.pdf - Published Version Download (1MB)

Abstract

Coronavirus disease (COVID-19) is caused by SARS-COV-2 and represents the causative agent of a potentially fatal and pandemic viral disease that is of great global public health concern and high transmutation rate and mechanisms. A comprehensive systematic search was performed on PubMed, Scopus, Web of Science, and Google Scholar, to find articles published until March 30, 2020. All relevant articles that reported clinical characteristics and laboratory result information of hospitalized COVID-19 patients were included in the analysis. Based on our analysis, however, articles not used RT-PCR and CT as were excluded all of the randomized controlled trial (RCT) were homogeneous (I2=94.58% and p≤0.001) statistical tests showed no publication bias/small study effect. Accordingly, the result of meta-analysis illustrated that RT-PCR increased cases of laboratory confirmation by more than 99% (95% CI: -1.3.0; 4.74) than other laboratory tests. As a result, this finding, is recommended to pilot and scale-up well and accurate laboratory techniques is used in developing countries, and is essential to prevent and control the pandemic diseases with spread in the world. However, it is recommended to further investigate the adverse effects of Real-time reverse transcriptase polymerase chain reaction (RT-PCR) before fully implementing the confirmation.

Item Type:	Article
Keywords:	COVID-19; Comprehensive systematic review; Meta-analysis; RT-PCR
Subjects:	Q Science > QR Microbiology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RB Pathology
Divisions:	Journal of Life Sciences and Biomedicine (JLSB)
Page Range:	pp. 1-11
Journal or Publication Title:	Journal of Life Science and Biomedicine
Journal Index:	Not Index
Volume:	13
Number:	1
Publisher:	Scienceline Publication
Identification Number:	https://doi.org/10.54203/jlsb.2023.1
ISSN:	2251-9939
Depositing User:	Dr. Zohreh Yousefi
URI:	https://eprints.science-line.com/id/eprint/1278

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