Outcomes of pregnant women with coronavirus disease 2019 (COVID-19) admitted to intensive care unit in Uzbekistan

IBADOV, Ravshan Alievich and ALIMOVA, Khilola Pulatovna and VOITOVA, Gavkhar Alisherovna (2022) Outcomes of pregnant women with coronavirus disease 2019 (COVID-19) admitted to intensive care unit in Uzbekistan. Journal of Life Science and Biomedicine. pp. 82-88. ISSN 2251-9939

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Abstract

Aim. The present study aimed to investigate outcomes of pregnant women with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2 or COVID-19) in the intensive care unit (ICU). Methods. A total of 3080 pregnant women infected with COVID-19 during treatment were studied in the maternity ward of the Zangiota-1 Republican Specialized Infectious Diseases Hospital from December 2020 to January, 2022. At the time of admission of patients to the hospital, 28.9% of women were in the first trimester of pregnancy, 34.3% and 36.8% were in the second and third trimester of pregnancy, respectively. 1980 cases (64.3%) showed a moderate course of pneumonia and in 48% (1478 cases), bilateral pneumonia was detected. At the same time, 60.0% of patients had lung damage (up to 50%) according to CT dataset. Results. A total of 677 out of 3080 pregnant women with COVID-19 pneumonia (22.0%) needed treatment at the ICU. 490 cases out of 677 patients showed severe clinical course of COVID-19, while 277 cases (41%) showed multiple organ dysfunction syndrome (MODS). Of 277 MODS cases, 209 (75.4%) were those in the third trimester of pregnancy and 170 (61.4%) had initially severe clinical picture of COVID-19. Mortality rate in ICU was 9.4% (64 cases out of 677) while 56.6% experienced post-traumatic stress disorder (PTSD) at baseline, 26.7% had general anxiety disorders, and 16.7% (113 of 677) of women experienced depression symptoms. In the postpartum period, 46.1% (312 of 677) cases showed combinations of PTSD, anxiety and depression according to the combined Patient Health Questionnaire Anxiety and Depression Scale (PHQ-ADS) assessment, which was typical for women with severe and extremely severe COVID-19, preterm birth, miscarriages and perinatal mortality. Conclusion. The ICU hospitalization rate for COVID-19 pneumonia in pregnant women was 22.0%, among which the vast majority (72.4%) were cases with severe clinical course of COVID-19 and PTSD (56.6%). Women in the third trimester of pregnancy were most susceptible to developing MODS and severe COVID-19 pneumonia. Recommendation. In promoting pregnant women's mental and physical health, understanding the characteristics of psycho-emotional stress disorders during the COVID-19 pandemic and learning how to deal with them is critical.

Item Type:	Article
Keywords:	COVID-19 pneumonia, Intensive care unit, Mental and physical health, Pregnant women
Subjects:	H Social Sciences > HQ The family. Marriage. Woman R Medicine > RA Public aspects of medicine R Medicine > RB Pathology R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Divisions:	Journal of Life Sciences and Biomedicine (JLSB)
Page Range:	pp. 82-88
Journal or Publication Title:	Journal of Life Science and Biomedicine
Journal Index:	Not Index
Volume:	12
Number:	5
Publisher:	Scienceline Publication
Identification Number:	https://doi.org/10.54203/jlsb.2022.10
ISSN:	2251-9939
Depositing User:	Dr. Zohreh Yousefi
URI:	https://eprints.science-line.com/id/eprint/1273

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