TY  - JOUR
N1  - Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Selangor, Serdang, 43400, Malaysia; Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Selangor, Serdang, 43400, Malaysia; University Veterinary Hospital, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Selangor, Serdang, 43400, Malaysia
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184743543&doi=10.54203%2fSCIL.2023.WVJ67&partnerID=40&md5=d61457622eaeadaf4da5620f407ca038
SP  - 626
Y1  - 2023/12/25/
AV  - public
A1  - Mazlan, M.
A1  - Syafiq, M.A.
A1  - Zakaria, M.A.
A1  - Samad, L.A.
A1  - Che-Amat, A.
KW  - Amorphous material; Bacterial infection; Gout tophi; Histopathology; Leopard gecko
EP  - 629
VL  - 13
SN  - 2322-4568
TI  - A Pathologic Case of Gout Tophi Deposition with a Concurrent Systemic Bacterial Infection in a Leopard Gecko (Eublepharis macularius)
N2  - Gout is caused by excessive uric acid in the blood deposited in tissues (visceral gout) or joints (articular gout), leading to severe inflammation and pain. A female leopard gecko was presented to the University Veterinary Hospital, University of Putra, Malaysia, with a history of swelling at the left caudal mandible, inappetence, and weight loss. An oral examination indicated a swollen mouth with scabs on the upper right mandible and multiple whitish deposits inside the mouth. The preliminary diagnosis was mouth rot, and the treatment included metronidazole and a multivitamin supplement. The leopard gecko died 12 days after treatment since there was no improvement. Post-mortem examination revealed that the liver was slightly enlarged with generalized moderate congestion and the presence of whitish deposits, as well as noticeable whitish deposits on the pleural surface of the lungs. Histopathological examination of the lungs revealed a granuloma with an inflammatory reaction predominantly by abundant mononuclear cells and fibrin deposition. An irregular collection of amorphous materials in the visceral pleura suggested gout tophi. The liver was infiltrated with amorphous material and fibrinous tissue, and it had mild congestion, indicating visceral gout and bacterial infection. Klebsiella pneumoniae and Proteus mirabilis were isolated from the lungs and liver samples, respectively. In conclusion, gout tophi is common in reptiles, but visceral involvement is rare, and early detection is critical to avoid secondary bacterial infection, as demonstrated in this case. © Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the articleâ??s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the articleâ??s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/.
PB  - SCIENCELINE
JF  - World's Veterinary Journal
IS  - 4
ID  - eprints957
ER  -