eprintid: 937
rev_number: 7
eprint_status: archive
userid: 5
dir: disk0/00/00/09/37
datestamp: 2024-03-16 22:42:30
lastmod: 2024-03-16 22:42:30
status_changed: 2024-03-16 22:42:30
type: article
metadata_visibility: show
creators_name: Zhelavskyi, M.
creators_name: Kernychnyi, S.
creators_name: Betlinska, T.
title: Effects of Hydroxychloroquine and Tacrolimus on Discoid Facial Lupus Erythematosus in a Dog
ispublished: pub
subjects: SF
divisions: j13
full_text_status: public
keywords: enrofloxacin; hydroxychloroquine; hydroxychloroquine sulfate; prednisolone; solcoseril; solcoseryl; tacrolimus, Article; cream; dermatomycosis; discoid lupus erythematosus; drug dose reduction; drug efficacy; drug safety; erythema; face; German shepherd; hyperemia; hyperpigmentation; male; nonhuman; papule; parasite; pruritus; remission; skin defect; sun exposure; tissue regeneration; Ukraine; veterinarian; veterinary clinic
note: Vinnytsia National Agrarian University, Sonyachna Str., 3, Vinnytsia, 21008, Ukraine; Higher educational institution Podillia State University, Shevchenko Str., 12, Kamyanets-Podilsky, 32302, Ukraine
abstract: Discoid lupus erythematosus is an autoimmune disease that affects the skin in dogs. 6-year-old male German Shepherd weighing 38 kg was taken to the Small Animal Hospital at the University in Kyiv, Ukraine, with a history of progressive skin lesions. The indications of discoid lupus erythematosus in dogs manifested as red, scaly macules or papules on the skin�s surface. These gradually develop into follicular plugging, disc-shaped plaques with adherent scales, and peripheral hyperpigmentation. The oral hydroxychloroquine was used for medication, and the prescribed dosage was 5.0 mg per kilogram of the dog�s weight, administered once daily. The hydroxychloroquine was gradually reduced and discontinued within a month. Concurrent with the hydroxychloroquine treatment, the application of tacrolimus cream (Protopic® 0.03) was initiated. The veterinary physician also advised the dog owner to limit sun exposure to avoid any adverse effects. After a four-week period, there was a decrease in pruritus and erythema, and plaques had flattened although the skin still had some patchy hyperpigmentation. Approximately 3-4 weeks later, the veterinarian determined that the dog had achieved clinical remission as all the skin lesions had become completely flattened. The use of deproteinized calf blood extract gel (Solcoseril® Gel for external 4.15 mg/1 g, Legacy led to the complete disappearance of the initial redness and prevented the appearance of new skin lesions. These results can be considered as a safe and effective alternative to conventional treatment methods. © The Author(s) 2023
date: 2023-06-25
publication: World's Veterinary Journal
volume: 13
number: 2
publisher: Scienceline Publication, Ltd
pagerange: 360-364
id_number: 10.54203/scil.2023.wvj39
refereed: TRUE
issn: 2322-4568
official_url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184766015&doi=10.54203%2fscil.2023.wvj39&partnerID=40&md5=6ea39afcd1129a8efdc86053ddcdf852
j_index: scopus
citation:    (2023)     Effects of Hydroxychloroquine and Tacrolimus on Discoid Facial Lupus Erythematosus in a Dog.   World's Veterinary Journal.  pp. 360-364.  ISSN 2322-4568   
document_url: http://eprints.science-line.com/id/eprint/937/1/WVJ%2013%282%29%2C%20360-364%2C%20June%2025%2C%202023.pdf