TY - JOUR TI - Effects of Hydroxychloroquine and Tacrolimus on Discoid Facial Lupus Erythematosus in a Dog SP - 360 SN - 2322-4568 EP - 364 N1 - Vinnytsia National Agrarian University, Sonyachna Str., 3, Vinnytsia, 21008, Ukraine; Higher educational institution Podillia State University, Shevchenko Str., 12, Kamyanets-Podilsky, 32302, Ukraine KW - enrofloxacin; hydroxychloroquine; hydroxychloroquine sulfate; prednisolone; solcoseril; solcoseryl; tacrolimus KW - Article; cream; dermatomycosis; discoid lupus erythematosus; drug dose reduction; drug efficacy; drug safety; erythema; face; German shepherd; hyperemia; hyperpigmentation; male; nonhuman; papule; parasite; pruritus; remission; skin defect; sun exposure; tissue regeneration; Ukraine; veterinarian; veterinary clinic AV - public A1 - Zhelavskyi, M. A1 - Kernychnyi, S. A1 - Betlinska, T. IS - 2 PB - Scienceline Publication, Ltd JF - World's Veterinary Journal VL - 13 Y1 - 2023/06/25/ ID - eprints937 N2 - Discoid lupus erythematosus is an autoimmune disease that affects the skin in dogs. 6-year-old male German Shepherd weighing 38 kg was taken to the Small Animal Hospital at the University in Kyiv, Ukraine, with a history of progressive skin lesions. The indications of discoid lupus erythematosus in dogs manifested as red, scaly macules or papules on the skin�??s surface. These gradually develop into follicular plugging, disc-shaped plaques with adherent scales, and peripheral hyperpigmentation. The oral hydroxychloroquine was used for medication, and the prescribed dosage was 5.0 mg per kilogram of the dog�??s weight, administered once daily. The hydroxychloroquine was gradually reduced and discontinued within a month. Concurrent with the hydroxychloroquine treatment, the application of tacrolimus cream (Protopic® 0.03) was initiated. The veterinary physician also advised the dog owner to limit sun exposure to avoid any adverse effects. After a four-week period, there was a decrease in pruritus and erythema, and plaques had flattened although the skin still had some patchy hyperpigmentation. Approximately 3-4 weeks later, the veterinarian determined that the dog had achieved clinical remission as all the skin lesions had become completely flattened. The use of deproteinized calf blood extract gel (Solcoseril® Gel for external 4.15 mg/1 g, Legacy led to the complete disappearance of the initial redness and prevented the appearance of new skin lesions. These results can be considered as a safe and effective alternative to conventional treatment methods. © The Author(s) 2023 UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184766015&doi=10.54203%2fscil.2023.wvj39&partnerID=40&md5=6ea39afcd1129a8efdc86053ddcdf852 ER -