<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Effects of Hydroxychloroquine and Tacrolimus on Discoid Facial Lupus Erythematosus in a Dog"^^ . "Discoid lupus erythematosus is an autoimmune disease that affects the skin in dogs. 6-year-old male German Shepherd weighing 38 kg was taken to the Small Animal Hospital at the University in Kyiv, Ukraine, with a history of progressive skin lesions. The indications of discoid lupus erythematosus in dogs manifested as red, scaly macules or papules on the skin�s surface. These gradually develop into follicular plugging, disc-shaped plaques with adherent scales, and peripheral hyperpigmentation. The oral hydroxychloroquine was used for medication, and the prescribed dosage was 5.0 mg per kilogram of the dog�s weight, administered once daily. The hydroxychloroquine was gradually reduced and discontinued within a month. Concurrent with the hydroxychloroquine treatment, the application of tacrolimus cream (Protopic® 0.03) was initiated. The veterinary physician also advised the dog owner to limit sun exposure to avoid any adverse effects. After a four-week period, there was a decrease in pruritus and erythema, and plaques had flattened although the skin still had some patchy hyperpigmentation. Approximately 3-4 weeks later, the veterinarian determined that the dog had achieved clinical remission as all the skin lesions had become completely flattened. The use of deproteinized calf blood extract gel (Solcoseril® Gel for external 4.15 mg/1 g, Legacy led to the complete disappearance of the initial redness and prevented the appearance of new skin lesions. These results can be considered as a safe and effective alternative to conventional treatment methods. © The Author(s) 2023"^^ . "2023-06-25" . . "13" . "2" . . "Scienceline Publication, Ltd"^^ . . . "World's Veterinary Journal"^^ . . . "23224568" . . . . . . . . . . . . . "S."^^ . "Kernychnyi"^^ . "S. Kernychnyi"^^ . . "T."^^ . "Betlinska"^^ . "T. Betlinska"^^ . . "M."^^ . "Zhelavskyi"^^ . "M. Zhelavskyi"^^ . . . . . . "Effects of Hydroxychloroquine and Tacrolimus on Discoid Facial Lupus Erythematosus in a Dog (Text)"^^ . . . . . "WVJ 13(2), 360-364, June 25, 2023.pdf"^^ . . "HTML Summary of #937 \n\n\n \n Effects of Hydroxychloroquine and Tacrolimus on Discoid Facial Lupus Erythematosus in a Dog\n \n\n" . "text/html" . . . "SF Animal culture"@en . .