@article{eprints937,
           title = {Effects of Hydroxychloroquine and Tacrolimus on Discoid Facial Lupus Erythematosus in a Dog},
            note = {Vinnytsia National Agrarian University, Sonyachna Str., 3, Vinnytsia, 21008, Ukraine; Higher educational institution Podillia State University, Shevchenko Str., 12, Kamyanets-Podilsky, 32302, Ukraine},
          author = {M. Zhelavskyi and S. Kernychnyi and T. Betlinska},
          number = {2},
       publisher = {Scienceline Publication, Ltd},
         journal = {World's Veterinary Journal},
            year = {2023},
           month = {June},
          volume = {13},
           pages = {360--364},
        keywords = {enrofloxacin; hydroxychloroquine; hydroxychloroquine sulfate; prednisolone; solcoseril; solcoseryl; tacrolimus, Article; cream; dermatomycosis; discoid lupus erythematosus; drug dose reduction; drug efficacy; drug safety; erythema; face; German shepherd; hyperemia; hyperpigmentation; male; nonhuman; papule; parasite; pruritus; remission; skin defect; sun exposure; tissue regeneration; Ukraine; veterinarian; veterinary clinic},
             url = {http://eprints.science-line.com/id/eprint/937/},
        abstract = {Discoid lupus erythematosus is an autoimmune disease that affects the skin in dogs. 6-year-old male German Shepherd weighing 38 kg was taken to the Small Animal Hospital at the University in Kyiv, Ukraine, with a history of progressive skin lesions. The indications of discoid lupus erythematosus in dogs manifested as red, scaly macules or papules on the skin{\^a}??s surface. These gradually develop into follicular plugging, disc-shaped plaques with adherent scales, and peripheral hyperpigmentation. The oral hydroxychloroquine was used for medication, and the prescribed dosage was 5.0 mg per kilogram of the dog{\^a}??s weight, administered once daily. The hydroxychloroquine was gradually reduced and discontinued within a month. Concurrent with the hydroxychloroquine treatment, the application of tacrolimus cream (Protopic{\^A}? 0.03) was initiated. The veterinary physician also advised the dog owner to limit sun exposure to avoid any adverse effects. After a four-week period, there was a decrease in pruritus and erythema, and plaques had flattened although the skin still had some patchy hyperpigmentation. Approximately 3-4 weeks later, the veterinarian determined that the dog had achieved clinical remission as all the skin lesions had become completely flattened. The use of deproteinized calf blood extract gel (Solcoseril{\^A}? Gel for external 4.15 mg/1 g, Legacy led to the complete disappearance of the initial redness and prevented the appearance of new skin lesions. These results can be considered as a safe and effective alternative to conventional treatment methods. {\^A}{\copyright} The Author(s) 2023}
}