eprintid: 817
rev_number: 8
eprint_status: archive
userid: 5
dir: disk0/00/00/08/17
datestamp: 2023-10-17 16:07:06
lastmod: 2023-10-17 16:07:06
status_changed: 2023-10-17 16:07:06
type: article
metadata_visibility: show
creators_name: Laxaphakdy, C.
creators_name: Jiwakanon, J.
creators_name: Supankong, S.
creators_name: Papirom, P.
creators_name: Tanpong, S.
creators_name: Porntrakulpipat, S.
title: The Effects of Grounded Herbs on the Intestinal Villus Height and Shedding of F18-positive Escherichia coli in Weaned Pigs
ispublished: pub
subjects: SF
divisions: j13
full_text_status: public
keywords: colistin; soybean protein, Andrographis paniculata; animal experiment; Article; body weight; controlled study; cross breeding; diarrhea; diet; digestive tract parameters; Duroc pig; Escherichia coli infection; Garcinia mangostana; herb; intestinal villi height; Landrace pig; male; nonhuman; pig; piglet; weaning; Yorkshire pig; Zingiber montanum
note: Research Group for Animal Health Technology, Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen, Thailand; The center of Excellence on Agricultural Biotechnology: (AG-BIO/PERDO-CHE), Bangkok, Thailand; Agricultural Biotechnology Research Center for Sustainable Economy, Khon Kaen University, Thailand; Division of Pathobiology, Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen, Thailand; Faculty of Agriculture, Khon Kaen University, Khon Kaen, Thailand
abstract: Antibiotics have been widely used to control and treat infections caused by Escherichia coli (E. coli) in weaned pigs. The bacteria resistance to antibiotics can occur naturally; however, the misuse of antibiotics can accelerate this resistance. New antibiotics are developed very slowly, and only two new classes of antibiotics have been developed in the past 40 years. This makes herbal medicine a promising method for fighting against antibiotic-resistant bacteria. In the current study, 25 male crossbred (Duroc x Landrace x Large white) weaned piglets with an average weight of 6-8 kg were examined for 24 days. The pigs were randomly assigned to five groups in a completely randomized design with five replicates (1 pig/pen). All treatments included 20 crude protein corn-soybean as the basal diet. The negative control group received no supplementation, while pigs in the second experimental group received a basal diet supplemented with 150 ppm colistin sulfate. Basal diet and herbal mixture (Andrographis paniculata, Zingiber cassumunar, and Garcinia mangostana) were fed to three other experimental groups at 500, 1000, and 2000 ppm. The F18-positive, colistin-resistant E. coli were orally inoculated to all pigs for 9 days. The antibacterial and anti-diarrheal effects of this diet and its effect on the inoculated pigs� intestinal villi were evaluated. The results indicated that supplementation of this herbal mixture at levels of 500, 1000, and 2000 ppm had antibacterial effects, with no significant difference between doses. However, the positive effects of this herbal mixture on intestinal villi height and diarrhea were found only in pigs that received 1000 and 2000 ppm of the herbal mixture. From a practical point of view, supplementation of this herbal mixture at 500 and 1000 ppm could be applied for prophylaxis during the weaning period, whereas 2000 ppm of the herbal mixture could be used for the treatment of postweaning E. coli diarrhea © 2023, World's Veterinary Journal.All Rights Reserved.
date: 2023-03-25
publication: World's Veterinary Journal
volume: 13
number: 1
publisher: Scienceline Publication, Ltd
pagerange: 75-84
id_number: 10.54203/scil.2023.wvj8
refereed: TRUE
issn: 2322-4568
official_url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85151888133&doi=10.54203%2fscil.2023.wvj8&partnerID=40&md5=1bfd54dff1f6f0243934d579777de0ac
j_index: scopus
citation:    (2023)     The Effects of Grounded Herbs on the Intestinal Villus Height and Shedding of F18-positive Escherichia coli in Weaned Pigs.   World's Veterinary Journal.  pp. 75-84.  ISSN 2322-4568   
document_url: http://eprints.science-line.com/id/eprint/817/1/WVJ%2013%281%29%2C%2075-84%2C%20March%2025%2C%202023.pdf