eprintid: 815
rev_number: 8
eprint_status: archive
userid: 5
dir: disk0/00/00/08/15
datestamp: 2023-10-17 16:06:04
lastmod: 2023-10-17 16:06:04
status_changed: 2023-10-17 16:06:04
type: article
metadata_visibility: show
creators_name: Sadr, S.
creators_name: Yousefsani, Z.
creators_name: Simab, P.A.
creators_name: Alizadeh, A.J.R.
creators_name: Lotfalizadeh, N.
creators_name: Borji, H.
title: Trichinella spiralis as a Potential Antitumor Agent: An Update
ispublished: pub
subjects: SF
divisions: j13
full_text_status: public
keywords: caveolin 1; heat shock protein; ribosome protein; translationally controlled tumor protein; tropomyosin, antineoplastic activity; apoptosis; Article; biological activity; biological therapy; cancer immunotherapy; cancer inhibition; human; liver cell carcinoma; lung cancer; malignant neoplasm; melanoma; nonhuman; parasite identification; protein function; therapy effect; treatment response; Trichinella spiralis; tumor growth
note: Department of Clinical Science, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran; Department of Pathobiology, Faculty of Veterinary Medicine, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran; Department of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran
abstract: Due to the limited success of therapeutic strategies in treating tumors, a new practical potent approach is needed. This review aimed to investigate previous literature related to tumors and Trichinella spiralis (T. spiralis). In recent years, there has been growing interest in utilizing biological, viral, bacterial, yeast, and parasitic agents to cure cancers. According to several studies, some parasites could interferee with the tumors� growth. There has been much discussion about some parasites� applications to cure tumors in animals and humans. In studies, T. spiralis was found to have antitumor properties. The active proteins in T. spiralis, such as Caveolin-1, Heat shock proteins, and Ribosomal proteins, are thought to inhibit the growth of cancers, such as melanoma, myeloma, sarcoma, leukemia, stomach cancer, colon cancer, breast cancer, and lung cancer. In addition, these proteins are thought to induce apoptosis in specific neoplastic cells. Accordingly, antigens derived from parasites may be helpful in cancer immunotherapy. However, there are still many unanswered questions regarding Trichinella spiralis� potential use as a biotherapy agent against cancer. Future studies should focus on the purification of parasite antigens and their use for wider-scale trials in animal models © 2023, World's Veterinary Journal.All Rights Reserved.
date: 2023-03-25
publication: World's Veterinary Journal
volume: 13
number: 1
publisher: Scienceline Publication, Ltd
pagerange: 65-74
id_number: 10.54203/scil.2023.wvj7
refereed: TRUE
issn: 2322-4568
official_url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85151905398&doi=10.54203%2fscil.2023.wvj7&partnerID=40&md5=cf1bc20a4cead1b522b6f9222c1578c2
j_index: scopus
citation:    (2023)     Trichinella spiralis as a Potential Antitumor Agent: An Update.   World's Veterinary Journal.  pp. 65-74.  ISSN 2322-4568   
document_url: http://eprints.science-line.com/id/eprint/815/1/WVJ%2013%281%29%2C%2065-74%20%2C%20March%2025%2C%202023.pdf