eprintid: 784
rev_number: 10
eprint_status: archive
userid: 5
dir: disk0/00/00/07/84
datestamp: 2023-10-17 15:39:36
lastmod: 2023-10-17 15:39:36
status_changed: 2023-10-17 15:39:36
type: article
metadata_visibility: show
creators_name: Nawfal, A.J.
creators_name: Al-Okaily, B.N.
title: Effect of the Sublethal Dose of Lead Acetate on Malondialdehyde, Dopamine, and Neuroglobin Concentrations in Rats
ispublished: pub
subjects: SF
divisions: j13
full_text_status: public
keywords: distilled water; dopamine; lead acetate; malonaldehyde; neuroglobin; neurotransmitter; sterile water, adult; animal experiment; Article; blood sampling; central nervous system; controlled study; dopamine blood level; exposure; male; nonhuman; oxidative stress; protein blood level; rat; sublethal dose
note: Department of Physiology and Medical Physics, College of Medicine, University of Fallujah, Anbar31020, Iraq; Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Baghdad, Baghdad, 10053, Iraq
abstract: Lead can have detrimental behavioral, biochemical, and physiological effects on the body. The current experiment was designed to estimate the sublethal dose of lead acetate that induce oxidative stress on the central nervous system (CNS) in adult using the probit analysis. Moreover, the current study examined the dose-response curve by successive doses of lead acetate on some parameters related to oxidative stress for 28 days. A total of 36 adult male rats were randomly selected and divided equally into six experimental groups and treated for 28 days. Rats in the control group received distilled sterile water, and those in G1, G2, G3, G4, and G5 were gavaged with 4, 8, 16, 32, and 64 mg/kg of lead acetate, respectively. The result indicated a positive correlation between the successive doses of lead acetate. Malondialdehyde concentration decreased dopamine and neuroglobin by increasing the dose of lead acetate in experimental groups (G3, G4, and G5), compared to the control group. In conclusion, exposure to the sublethal dose of 16 mg/kg of lead acetate significantly alters the levels of the neurotransmitters and increases the production of oxidative stress in the CNS tissue. © 2022, World''s Veterinary Journal. All Rights Reserved.
date: 2022-09-25
publication: World's Veterinary Journal
volume: 12
number: 3
publisher: Scienceline Publication, Ltd
pagerange: 311-315
id_number: 10.54203/SCIL.2022.WVJ39
refereed: TRUE
issn: 2322-4568
official_url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85145953896&doi=10.54203%2fSCIL.2022.WVJ39&partnerID=40&md5=746ca2289da313cb2ca8800ef7fae3db
j_index: scopus
citation:    (2022)     Effect of the Sublethal Dose of Lead Acetate on Malondialdehyde, Dopamine, and Neuroglobin Concentrations in Rats.   World's Veterinary Journal.  pp. 311-315.  ISSN 2322-4568   
document_url: http://eprints.science-line.com/id/eprint/784/1/article/74/WVJ%2012%283%29%2C%20311-315%2C%20September%2025%2C%202022.pdf