TY  - JOUR
JF  - World's Veterinary Journal
TI  - Effect of the Sublethal Dose of Lead Acetate on Malondialdehyde, Dopamine, and Neuroglobin Concentrations in Rats
IS  - 3
A1  - Nawfal, A.J.
A1  - Al-Okaily, B.N.
EP  - 315
ID  - eprints784
VL  - 12
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85145953896&doi=10.54203%2fSCIL.2022.WVJ39&partnerID=40&md5=746ca2289da313cb2ca8800ef7fae3db
AV  - public
N1  - Department of Physiology and Medical Physics, College of Medicine, University of Fallujah, Anbar31020, Iraq; Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Baghdad, Baghdad, 10053, Iraq
SN  - 2322-4568
Y1  - 2022/09/25/
KW  - distilled water; dopamine; lead acetate; malonaldehyde; neuroglobin; neurotransmitter; sterile water
KW  -  adult; animal experiment; Article; blood sampling; central nervous system; controlled study; dopamine blood level; exposure; male; nonhuman; oxidative stress; protein blood level; rat; sublethal dose
PB  - Scienceline Publication, Ltd
SP  - 311
N2  - Lead can have detrimental behavioral, biochemical, and physiological effects on the body. The current experiment was designed to estimate the sublethal dose of lead acetate that induce oxidative stress on the central nervous system (CNS) in adult using the probit analysis. Moreover, the current study examined the dose-response curve by successive doses of lead acetate on some parameters related to oxidative stress for 28 days. A total of 36 adult male rats were randomly selected and divided equally into six experimental groups and treated for 28 days. Rats in the control group received distilled sterile water, and those in G1, G2, G3, G4, and G5 were gavaged with 4, 8, 16, 32, and 64 mg/kg of lead acetate, respectively. The result indicated a positive correlation between the successive doses of lead acetate. Malondialdehyde concentration decreased dopamine and neuroglobin by increasing the dose of lead acetate in experimental groups (G3, G4, and G5), compared to the control group. In conclusion, exposure to the sublethal dose of 16 mg/kg of lead acetate significantly alters the levels of the neurotransmitters and increases the production of oxidative stress in the CNS tissue. © 2022, World''s Veterinary Journal. All Rights Reserved.
ER  -