@article{eprints570,
           month = {September},
          author = {Ravshan Aliyevich IBADOV and Anvar Shamkhatovich ARIFJANOV and Sardor Khamdamovich IBRAGIMOV and Begali Bobokulovich KHAKIMOV},
            year = {2021},
           pages = {80--87},
       publisher = {Scienceline Publications, Ltd},
          number = {05},
          volume = {11},
           title = {Dexmedetomidine for sedation and correction of psychoemotional disorders in critically ill patients with COVID-19},
         journal = {Journal of Life Science and Biomedicine},
        keywords = {COVID-19,  Intensive care unit, Depression, Anxiety, Posttraumatic stress Disorder, Sedation, Dexmedetomidine, Comparison study},
        abstract = {Aim. The objective of this study was to evaluate sedation therapy effectiveness in critically ill patients with severe COVID-19 who received dexmedetomidine compared to propofol. Methods. The research was done in a prospective single center to a cohort study of critically ill 333 adult patients with COVID-19 and psychoemotional disorders (depression, anxiety and posttraumatic stress disorder) admitted in the ICU of the Republican Specialized Hospital for COVID-19 in Uzbekistan. Patients were non-invasive ventilated more than 24 hours and received intravenous sedation with dexmedetomidine or propofol. Results. The risk of progression of the pathological process decreased from 47.6\% to 21.8\% and, accordingly, the proportion of patients with stabilization and improvement of their condition increased from 52.4\% to 79.4\% (p{\ensuremath{<}}0.001). The possibilities of non-invasive respiratory support were expanded with a reduction in the frequency of tracheal intubations from 17.3\% to 7.3\% (p{\ensuremath{<}}0.001), the duration of ICU stay was from 12.6{$\pm$}0.8 to 9.4{$\pm$}0.6 days, and the duration of respiratory therapy was from 8.4{$\pm$}0.5 to 5.2{$\pm$}0.4 days. In particular, there was an improvement in oxygen saturation (SpO2) recovery after one day of intensive therapy from 86.6{$\pm$}0.2\% to 92.2{$\pm$}0.3\% with non-invasive ventilation and a higher oxygenation index (2.3 in the dexmedetomidine group versus 1.6 in the propofol group, p=0.032) during the period of sedation withdrawal. Conclusion. In the presence of severe psychoemotional disorders, the effectiveness of etiotropic and pathogenetic treatment protocols of COVID-19 directly depends on the proper sedation regimen. In this aspect, dexmedetomidine provides adequate and safe respiratory support with an improvement in external respiration, blood gas composition and a minimal negative hemodynamic effect.},
             url = {http://eprints.science-line.com/id/eprint/570/}
}