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primary topic: Role of Elastin Expression in Thickening the Postpartum Vaginal Wall in Virgin and Postpartum Rat Models

Role of Elastin Expression in Thickening the Postpartum Vaginal Wall in Virgin and Postpartum Rat Models
type: AcademicArticle
type: Article
abstract: Childbirth induces a number of alterations, including ligament weakening and increased vaginal distensibility. The occurrence of vaginal laxity or distensibility is associated with the vaginal wall and introitus overstretching during vaginal parturition while the pathophysiology is due to increased levator dimension and trauma to the levator ani muscle through avulsion (macrotrauma) or overdistension (microtrauma). Elastin is an extracellular matrix protein that confers elastic properties to organs and tissues, particularly those requiring elasticity. Elastin plays a vital role in the functioning of numerous tissues, such as the lungs, blood vessels, heart valves, ligaments, tendons, and skin. It is also a component of the vaginal mucosa. The aim of the present was to evaluate the role of elastin in the thickening of the postpartum vaginal wall composed of epithelial mucosa, and to understand the mechanism underlying vaginal laxity or distensibility within parous and nulliparous animal models. A total of 32 female white rats (Rattus norvegicus) were used in the present study. They were divided into two groups, each group consisting of 16 rats. The control group (C0) consisted of virgin nulliparous rats, which were sacrificed on the second day after vaginal parturition. Pregnant rats (group C1) were sacrificed on the second day after vaginal parturition. The median elastin expression in group C1 was higher (3 ± 0.56) than group C0 (2.85 ± 0.75). The mean thickness of the vaginal mucosal epithelium in group C0 (56,8 931µm) was greater than group C1 (44,98 349µm). The comparison of vaginal mucosal epithelium thickness between the two groups indicated a significant difference between groups C0 and C1. Elastin levels were significantly correlated with epithelial thickness. The expression of elastin significantly affects the vaginal wall thickness, which further affects vaginal laxity or vaginal distensibility.
date: 2021-06-25
volume: 11
issue: 2
is part of: World's Veterinary Journal
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Role of Elastin Expression in Thickening the Postpartum Vaginal Wall in Virgin and Postpartum Rat Models (Text)
has version: Role of Elastin Expression in Thickening the Postpartum Vaginal Wall in Virgin and Postpartum Rat Models (Text)
has published: Role of Elastin Expression in Thickening the Postpartum Vaginal Wall in Virgin and Postpartum Rat Models (Text)
has document: Role of Elastin Expression in Thickening the Postpartum Vaginal Wall in Virgin and Postpartum Rat Models (Other)
subject: Q Science (General)
subject: SF Animal culture

Role of Elastin Expression in Thickening the Postpartum Vaginal Wall in Virgin and Postpartum Rat Models (Text)
type: Document
has file: WVJ 11(2) 228-234, June 25, 2021.pdf
has part: WVJ 11(2) 228-234, June 25, 2021.pdf

Scienceline Publication, Ltd
type: Organization

World's Veterinary Journal
type: Collection
issn: 23224568

B. Santoso
type: Person
given name: B.
family name: Santoso

M. Yulianto Listiawan
type: Person
given name: M.
family name: Yulianto Listiawan

B. A. Tjokroprawiro
type: Person
given name: B. A.
family name: Tjokroprawiro

C. R. S. Prakoeswa
type: Person
given name: C. R. S.
family name: Prakoeswa

T. Setyaningrum
type: Person
given name: T.
family name: Setyaningrum

W. Widjiati
type: Person
given name: W.
family name: Widjiati

Role of Elastin Expression in Thickening the Postpartum Vaginal Wall in Virgin and Postpartum Rat Models (Other)
type: Document
is version of: Role of Elastin Expression in Thickening the Postpartum Vaginal Wall in Virgin and Postpartum Rat Models (Text)
is volatile version of: Role of Elastin Expression in Thickening the Postpartum Vaginal Wall in Virgin and Postpartum Rat Models (Text)
is index codes version of: Role of Elastin Expression in Thickening the Postpartum Vaginal Wall in Virgin and Postpartum Rat Models (Text)
has file: indexcodes.txt
has part: indexcodes.txt

http://eprints.science-line.com/id/eprint/520/
title: HTML Summary of #520 <epc:when xmlns:epc="http://eprints.org/ep3/control" test="title">Role of Elastin Expression in Thickening the Postpartum Vaginal Wall in Virgin and Postpartum Rat Models</epc:when>
format: text/html
primary topic: Role of Elastin Expression in Thickening the Postpartum Vaginal Wall in Virgin and Postpartum Rat Models

Q Science (General)
type: Concept

SF Animal culture
type: Concept