@article{eprints165,
           month = {June},
          author = {A. M. El Nabarawy and K. Madian and I. B. Shaheed and W. A. Abd El-Ghany},
            year = {2020},
           pages = {223--234},
       publisher = {Scienceline Publication, Ltd},
          number = {2s},
          volume = {10},
           title = {Comparative Evaluation of Different Antimycotoxins for Controlling Mycotoxicosis in Broiler Chickens},
         journal = {Journal of World's Poultry Research},
        keywords = {Acids, Antioxidants, Formaldehyde, Immunostimulant, Mycotoxins, Poultry},
        abstract = {Natural contamination of feedstuffs with mycotoxins is considered a major problem affecting the poultry industry in Egypt. Accordingly, this study aimed to compare the ability of different antimycotoxin compounds in the control of mycotoxicosis caused by naturally contaminated diet in broiler chickens. A total of 180 day-old broiler chicks were divided into six groups (30 chicks each group) and kept for a 5-week experimental period. Group 1 was kept as control negative (non mycotoxicated or treated), while group 2 was kept as a positive control (mycotoxicated only). Groups 2-6 were fed ration contaminated with 11 ppb aflatoxins, 3.9 ppb ochratoxins, and 4.2 ppm zearalenone. Groups 3-6 were kept in mycotoxicated ration until 2 weeks of age when clinical signs and lesions were suggestive for mycotoxicosis. Groups 3, 4 and 5 were treated with biological, antioxidant, immunostimulant compounds; respectively. Biological, antioxidants and immunostimulant compounds were given in the drinking water. In group 6, ration was treated with formaldehyde vapor. Performance parameters including body weight, feed consumption and feed conversion rate were recorded weekly. Clinical signs, mortalities and lesions were observed. Serum samples were collected for determination of immunological profile to infectious bursal disease (IBD) virus vaccine. Moreover, liver, kidney and bursa of Fabricius were collected for histopathological examination. Muscles and liver tissue samples were collected for determination of aflatoxins residues. Results revealed significant improvement in performance parameters in treated groups in comparison to non-treated mycotoxicated group, however, antioxidants-treated birds showed the highest performance. The severity of clinical signs and lesions were reduced in the treated chickens compared to non-treated mycotoxicated ones. Significant modulation in immune response toward IBD virus was observed in all treated chickens compared to non-treated mycotoxicated chickens. Histopathological examination of organs of control mycotoxicated birds showed severe degenerative changes which became mild in bursa of Fabricius while returned to normal histological structure in liver and kidney. Residues of aflatoxins in tissues of all groups exceeded the permissible limit with high levels in mycotoxicated control positive group. In conclusion, water treatments with some antimycotoxin agents like biological, antioxidants and immunostimulant compounds greatly counteracted the adverse effect of the naturally contaminated ration with different mycotoxins.},
             url = {http://eprints.science-line.com/id/eprint/165/}
}