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primary topic: Impact of Polyherbal Formulation on Transcriptome Profiling of Chicken Breast Muscle: Elucidation of Molecular Mechanisms for the Enhanced Cellular Feed Efficiency in Broiler Chickens

Impact of Polyherbal Formulation on Transcriptome Profiling of Chicken Breast Muscle: Elucidation of Molecular Mechanisms for the Enhanced Cellular Feed Efficiency in Broiler Chickens
type: AcademicArticle
type: Article
abstract: To elucidate the cellular mechanisms underlying feed efficiency (FE) enhanced by polyherbal formulation (PHF), a combination of Andrographis paniculata, Punica granatum, and Emblica officinalis, the microarray technology was used to identify the genetic pathways related to feed utilization through genomical profiling of breast muscle in Cobb broiler chickens supplemented with or without PHF. 300 male day-old chicks were randomly distributed into two groups of 6 replicates with 25 each, including control (basal-diet) and PHF (Basal-diet+PHF-400g/ton), and their impact on performance parameters was assessed on day 42. Similarly, the global gene expression of breast muscles collected in each group was profiled using Agilent chicken whole genome microarray technology. Further, the Database for Annotation Visualization and Integrated Discovery (DAVID) Bioinformatics Resources and gene ontology (GO) analysis were used to identify the functional clustering of differentially expressed genes (DEGs) and gene network pathways associated with FE. RT-qPCR was subsequently conducted to cross-validate the expression of genes identified by DAVID. The PHF supplementation significantly improved the body weight gain (BWG) and feed conversion ratio in broilers compared to the control. Totally, 1338 DEGs (756 up-regulated and 582 down-regulated) were identified, of which 732 DEGs of PHF were significantly different from the control group. However, bioinformatics analysis revealed a significant modulation of 198 DEGs (94 up-regulated and 104 down-regulated) after hierarchical clustering, whose collective expression indicates significant enrichment of FE-related biological processes in the PHF-treated group. Further, a deeper understanding of the following DEGs (ND1, ND2, ND3, ND4, ND4L, ND5, ND6 CYTB, COX1, COX2, COX3, ATP6, PGC1-α, PPAR, MEF2, PARK2, Wnt3A, Wnt11, Golgb1, and IGF1) was established by mapping with Kyoto-Encylopedia-of-Genes-and-Genomes (KEGG) pathway in relation to mitoc…
date: 2025-06-31
volume: 15
issue: 2
is part of: Journal of World’s Poultry Research
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Impact of Polyherbal Formulation on Transcriptome Profiling of Chicken Breast Muscle: Elucidation of Molecular Mechanisms for the Enhanced Cellular Feed Efficiency in Broiler Chickens (Text)
has version: Impact of Polyherbal Formulation on Transcriptome Profiling of Chicken Breast Muscle: Elucidation of Molecular Mechanisms for the Enhanced Cellular Feed Efficiency in Broiler Chickens (Text)
has published: Impact of Polyherbal Formulation on Transcriptome Profiling of Chicken Breast Muscle: Elucidation of Molecular Mechanisms for the Enhanced Cellular Feed Efficiency in Broiler Chickens (Text)
subject: SF Animal culture

Impact of Polyherbal Formulation on Transcriptome Profiling of Chicken Breast Muscle: Elucidation of Molecular Mechanisms for the Enhanced Cellular Feed Efficiency in Broiler Chickens (Text)
type: Document
has file: JWPR15(2)194-207,2025 (1).pdf
has part: JWPR15(2)194-207,2025 (1).pdf

Scienceline Publication
type: Organization

Journal of World’s Poultry Research
type: Collection
issn: 2322455X

Saravanakumar Marimuthu
type: Person
given name: Saravanakumar
family name: Marimuthu

Subramaniyam Suresh
type: Person
given name: Subramaniyam
family name: Suresh

Prashanth D'Souza
type: Person
given name: Prashanth
family name: D'Souza

http://eprints.science-line.com/id/eprint/1611/
title: HTML Summary of #1611 <epc:when xmlns:epc="http://eprints.org/ep3/control" test="title">Impact of Polyherbal Formulation on Transcriptome Profiling of Chicken Breast Muscle: Elucidation of Molecular Mechanisms for the Enhanced Cellular Feed Efficiency in Broiler Chickens</epc:when>
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primary topic: Impact of Polyherbal Formulation on Transcriptome Profiling of Chicken Breast Muscle: Elucidation of Molecular Mechanisms for the Enhanced Cellular Feed Efficiency in Broiler Chickens

SF Animal culture
type: Concept