%D 2025 %P 139-150 %V 15 %I Scienceline Publication %R 10.36380/jwpr.2025.14 %X The choice of litter type (LT) in broiler chicken production can significantly influence overall performance and health. Adding specific combinations of L-selenomethionine and Vitamin E (L-SeMet + V.E) to drinking water can impact broiler chickens’ health. This study aimed to explore the effects of two LT types, wood shavings (WS) and perforated plastic litter (PL) as well as water supplementation with L-SeMet + V.E, on growth performance, blood parameters, antioxidant capacity, and thyroid hormone levels in broiler chickens. A total of 312 one-day-old male broiler chickens were randomly assigned to two different LT groups (WS and PL), with 156 chicks in each. Within each LT group, the chickens were further divided into four subgroups: a control group (T0) that received plain water, and three treatment groups that received drinking water supplements. Each subgroup consisted of three replicates, with 13 broiler chickens per replicate. The water treatments involved varying levels of supplementation with L-SeMet and vitamin E: T1 (0.5 mg/L + 250 mg/L), T2 (1 mg/L + 250 mg/L), and T3 (1.5 mg/L + 250 mg/L). Chickens were assessed for growth performance, feed efficiency, and blood biochemical parameters including lipids, liver enzymes, antioxidants, and thyroid hormones. Chickens raised on PL and receiving T3 exhibited significantly enhanced performance and feed efficiency, outperforming those raised on WS and given different supplementation levels. Significant enhancements were observed in the blood lipid profile and liver enzyme levels across the different LT groups, with the highest values recorded in the PL group. Additionally, broiler chicken in the T2 group, along with the WS × T2 and PL × T3 interactions, showed a notable improvement in blood biochemical parameters. Similarly, chickens raised on PL and given T3-supplemented water, along with the interactions WS × T2 and PL × T3, showed a significant improvement in antioxidant status and thyroid hormone levels in comparison to chickens raised on WS and the other treatment combinations. The use of PL and supplemenation with L-SeMet + V.E in drinking water were found to enhance growth performance, improve blood parameters, increase antioxidant capacity, and influence thyroid hormone levels in broiler chickens. %A Eman Mohamed Rady %A Gaafar EL-Gendi %A Osama El-Garhy %N 2 %T The Interplay of Litter Types, Blends of L-selenomethionine, and Vitamin E in Broiler Chicken’s Performance and Health %K Antioxidant, Broiler chicken, L-selenomethionine and Vitamin E, Productivity, Thyroid hormone %L eprints1605 %J Journal of World’s Poultry Research