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primary topic: Effects of Black Garlic (Allium sativum) Supplementation on Oxidative Stress and Leptin Level in Male Obese Rats

Effects of Black Garlic (Allium sativum) Supplementation on Oxidative Stress and Leptin Level in Male Obese Rats
type: AcademicArticle
type: Article
abstract: Obesity is characterized by excessive fat accumulation in tissues, leading to leptin resistance and chronic inflammation. Black garlic is a well-documented natural remedy capable of improving leptin resistance and oxidative stress through its antioxidant compounds, such as S-Allyl cysteine and polyphenol flavonoids. The present study aimed to evaluate the effects of black garlic on oxidative stress and leptin levels in obese male rats. Twenty-five adult male Wistar rats, aged 10 to 12 weeks and weighing approximately 200 g, were divided into five experimental groups, each comprising five rats. These groups included a negative control group fed a standard diet (K1), a positive control group given a high-fat diet (K2), Treatment group 1 receiving a high-fat diet plus 200 mg of black garlic (P1), Treatment group 2 receiving a high-fat diet plus 400 mg of black garlic (P2), and Treatment group 3 receiving a high-fat diet plus 800 mg of black garlic (P3). The rats received black garlic orally for 28 days. The blood samples were analyzed for markers of oxidative stress, specifically malondialdehyde, as well as leptin levels. The present findings indicated that black garlic significantly decreased malondialdehyde and leptin concentrations in groups P1, P2, and P3 compared to the positive control group. Black garlic, administered at doses of 200, 400, and 800 mg, demonstrated the capacity to diminish oxidative stress and leptin levels in obese male rats.
date: 2025-09-30
volume: 15
issue: 3
is part of: World’s Veterinary Journal
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ConferenceItemEPrint
is part of: repository
has document: Effects of Black Garlic (Allium sativum) Supplementation on Oxidative Stress and Leptin Level in Male Obese Rats (Text)
has version: Effects of Black Garlic (Allium sativum) Supplementation on Oxidative Stress and Leptin Level in Male Obese Rats (Text)
has published: Effects of Black Garlic (Allium sativum) Supplementation on Oxidative Stress and Leptin Level in Male Obese Rats (Text)
subject: SF Animal culture

Effects of Black Garlic (Allium sativum) Supplementation on Oxidative Stress and Leptin Level in Male Obese Rats (Text)
type: Document
has file: WVJ15(3)774-781,2025 (1).pdf
has part: WVJ15(3)774-781,2025 (1).pdf

World’s Veterinary Journal
type: Collection
issn: 23224568

Endrinaldi
type: Person
family name: Endrinaldi

Eti Yerizel
type: Person
given name: Eti
family name: Yerizel

Ibrahim
type: Person
family name: Ibrahim

HTML Summary of #1598 Conference or Workshop Item #1598
format: text/html
primary topic: Effects of Black Garlic (Allium sativum) Supplementation on Oxidative Stress and Leptin Level in Male Obese Rats

SF Animal culture
type: Concept