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primary topic: Advances in Hyaluronic Acid-Based Therapies

Advances in Hyaluronic Acid-Based Therapies
type: AcademicArticle
type: Article
abstract: Hyaluronic acid (HA) is crucial in regulating stem cells and enhancing their therapeutic efficacy in chronic inflammatory diseases such as interstitial cystitis/bladder pain syndrome )IC/BPS(. This study aimed to explore the potential of HA as a biomaterial for optimizing stem cell-based therapies in the treatment of IC/BPS. Due to its biocompatibility and bioactivity, HA serves as a supportive matrix that improves stem cell retention, survival, and function. Additionally, HA modulates stem cell behavior, promoting regeneration and anti-inflammatory response, which are essential for repairing the damaged bladder lining in animals. Its intrinsic anti-inflammatory properties further contribute to reducing inflammation and creating a favorable microenvironment for mesenchymal stem cells (MSCs). Furthermore, HA facilitates the controlled release of MSCs and other therapeutic agents, extending their benefits for chronic conditions like IC/BPS. The wide-ranging applications of HA in both animal models and human research underscore its potential as a therapeutic agent for various medical conditions. Preclinical studies have shown that HA supports tissue regeneration, reduces inflammation, and enhances stem cell retention, making it a valuable biomaterial for treating bladder inflammation, liver fibrosis, and cardiovascular disorders. In clinical settings, HA has been effectively applied in regenerative medicine, osteoarthritis management, wound healing, and drug delivery, demonstrating its biocompatibility and therapeutic effectiveness. These insights highlight HA’s role in translating experimental findings into clinical applications, paving the way for improved treatment approaches for chronic and inflammatory diseases. Overall, HA holds significant potential in enhancing the efficacy and long-term therapeutic outcomes of MSC-based treatments for chronic bladder disorders.
date: 2025-06-25
volume: 15
issue: 2
is part of: World’s Veterinary Journal
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Advances in Hyaluronic Acid-Based Therapies (Text)
has version: Advances in Hyaluronic Acid-Based Therapies (Text)
has published: Advances in Hyaluronic Acid-Based Therapies (Text)
subject: SF Animal culture

Advances in Hyaluronic Acid-Based Therapies (Text)
type: Document
has file: WVJ15(2)543-548,2025 (1).pdf
has part: WVJ15(2)543-548,2025 (1).pdf

Scienceline Publication
type: Organization

World’s Veterinary Journal
type: Collection
issn: 23224568

Mahmoud Abdel-maboud
type: Person
given name: Mahmoud
family name: Abdel-maboud

Nashwa Barakat
type: Person
given name: Nashwa
family name: Barakat

Nada A. Elhossieny
type: Person
given name: Nada A.
family name: Elhossieny

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primary topic: Advances in Hyaluronic Acid-Based Therapies

SF Animal culture
type: Concept