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primary topic: Association of Genetic Polymorphisms in HSF1 and HSPA6 Genes with Growth and Adaptation traits in Barki Lambs

Association of Genetic Polymorphisms in HSF1 and HSPA6 Genes with Growth and Adaptation traits in Barki Lambs
type: AcademicArticle
type: Article
abstract: Barki is a sheep breed that is well-adapted to the harsh environmental conditions in Egypt without compromising its reproduction and productivity. Further, it remarkably contributes to the livelihood of many breeders, particularly in the desert regions of Egypt. This study investigated potential polymorphisms in the HSF1 and HSPA6 genes and their impacts on growth, adaptation traits, and blood parameters in 194 Barki lambs. Growth traits included birth weight, weaning weight (WW), and weights at 6 (W6) and 9 (W9) months of age. Adaptation traits included respiration rate, heart rate, body temperature, rectal temperature, and hormonal and biochemical blood profiles. The PCR-Restricted Fragment Length Polymorphism technique was applied to detect the allelic and genotypic frequencies of HSF1 and HSPA6 genes using SmaI and Cfr42I (SacII) restriction enzymes, respectively. The HSF1 exhibited two alleles (A and B) with only two genotypes, AB (0.46) and BB (0.52). However, the HSPA6 gene showed a monomorphic pattern. Association analysis revealed a significant effect of the HSF1 polymorphism on WW, W6, and W9. However, neither HSPA6 nor HSF1 polymorphisms significantly influenced adaptation traits or blood parameters. Lambs carrying AB genotypes had a relatively higher WW (16.14 kg) than BB lambs (13.7 kg). The fixed effect of lamb sex was significant on the weight at 9 months, with values of 34.43 kg for males and 28.17 kg for females. Male lambs were significantly heavier than females. Furthermore, lamb sex had a significant effect on respiratory rate (69.35 rpm for males and 60.48 for females), heart rate (87.48 rpm for males and 95.1 for females), urea (74 mg/dl for males and 41.21 mg/dl for females), aspartate aminotransferase (92.6 IU/L for males and 87.92 IU/L for females) and T3 hormone (2.75 ng/ml for males and 2.29 ng/ml for females). These findings elucidated that the HSF1 gene can be considered a functional candidate for improving growth performance in Barki la…
date: 2025-06-25
volume: 15
issue: 2
is part of: World’s Veterinary Journal
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Association of Genetic Polymorphisms in HSF1 and HSPA6 Genes with Growth and Adaptation traits in Barki Lambs (Text)
has version: Association of Genetic Polymorphisms in HSF1 and HSPA6 Genes with Growth and Adaptation traits in Barki Lambs (Text)
has published: Association of Genetic Polymorphisms in HSF1 and HSPA6 Genes with Growth and Adaptation traits in Barki Lambs (Text)
subject: SF Animal culture

Association of Genetic Polymorphisms in HSF1 and HSPA6 Genes with Growth and Adaptation traits in Barki Lambs (Text)
type: Document
has file: WVJ15(2)477-486, 2025 (1).pdf
has part: WVJ15(2)477-486, 2025 (1).pdf

Scienceline Publication
type: Organization

World’s Veterinary Journal
type: Collection
issn: 23224568

Ismail Mohamed Ismail
type: Person
given name: Ismail
family name: Mohamed Ismail

Ibrahim Samir Abd El-Hamid
type: Person
given name: Ibrahim Samir Abd
family name: El-Hamid

Ibrahim Abousoliman
type: Person
given name: Ibrahim
family name: Abousoliman

http://eprints.science-line.com/id/eprint/1567/
title: HTML Summary of #1567 <epc:when xmlns:epc="http://eprints.org/ep3/control" test="title">Association of Genetic Polymorphisms in HSF1 and HSPA6 Genes with Growth and Adaptation traits in Barki Lambs</epc:when>
format: text/html
primary topic: Association of Genetic Polymorphisms in HSF1 and HSPA6 Genes with Growth and Adaptation traits in Barki Lambs

SF Animal culture
type: Concept