…
comment: The repository administrator has not yet configured an RDF license.
primary topic: Transient Paralysis Associated with Marek’s Disease Virus (MDV) in a Poultry Flock

Transient Paralysis Associated with Marek’s Disease Virus (MDV) in a Poultry Flock
type: AcademicArticle
type: Article
abstract: Transient paralysis (TP) is a non-neoplastic neurological disorder in poultry caused by Marek’s Disease Virus (MDV). It is characterized by temporary ataxia and paresis, primarily due to inflammatory damage in the central nervous system (CNS) rather than neoplastic transformation. The present study reported an outbreak of MDV-induced TP in a commercial 80,000 Lohmann LSL-Lite layer flock aged 95 days in Alborz Province, Iran, where affected hens exhibited sudden-onset paralysis and ataxia, with those that survived recovering spontaneously within three to five days without intervention. Although the flock had been vaccinated against MDV at hatch, neurological signs appeared at 95 days of age. Cerebellar samples were collected from ten clinically affected hens, including five collected postmortem from deceased chickens and five from live chickens that were humanely euthanized. Real-time polymerase chain reaction (PCR) confirmed infection with MDV field strains through strong amplification of pp38-Vir (1) and pp38-Vir (3) probes. In contrast, the CVI988 vaccine strain was not detected in samples collected at 95 days post-vaccination, which raised concerns regarding the quality of the vaccine and the proper administration of vaccination protocols. Histopathological examination of cerebellar tissues from three hens revealed vasogenic edema, perivascular cuffing, vasculitis, and widespread inflammatory cell infiltration. No evidence of tumor formation, mitotic activity, or neoplastic lymphoid proliferation was observed. These findings helped to distinguish TP from classical neoplastic Marek’s Disease. The present study highlighted the need for early and accurate differentiation of TP from other neurological disorders, such as ionophore toxicity, botulism, and vitamin deficiencies, given its transient condition. The occurrence of TP in a vaccinated flock emphasizes the complexity of MDV pathogenesis, possible shortcomings in vaccine efficacy or its application practices, a…
date: 2025-06-25
volume: 15
issue: 2
is part of: World’s Veterinary Journal
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Transient Paralysis Associated with Marek’s Disease Virus (MDV) in a Poultry Flock (Text)
has version: Transient Paralysis Associated with Marek’s Disease Virus (MDV) in a Poultry Flock (Text)
has published: Transient Paralysis Associated with Marek’s Disease Virus (MDV) in a Poultry Flock (Text)
subject: SF Animal culture

Transient Paralysis Associated with Marek’s Disease Virus (MDV) in a Poultry Flock (Text)
type: Document
has file: WVJ15(2)399-406,2025 (1).pdf
has part: WVJ15(2)399-406,2025 (1).pdf

Scienceline Publication
type: Organization

World’s Veterinary Journal
type: Collection
issn: 23224568

Mohammad Barari
type: Person
given name: Mohammad
family name: Barari

Omid Dezfoulian
type: Person
given name: Omid
family name: Dezfoulian

Mohammad Reza Danaeifard
type: Person
given name: Mohammad Reza
family name: Danaeifard

HTML Summary of #1558 <epc:when xmlns:epc="http://eprints.org/ep3/control" test="title">Transient Paralysis Associated with Marek’s Disease Virus (MDV) in a Poultry Flock</epc:when>
format: text/html
primary topic: Transient Paralysis Associated with Marek’s Disease Virus (MDV) in a Poultry Flock

SF Animal culture
type: Concept