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primary topic: Effect of Crescentia cujete (L.) Fruit Extract as a Thread-Coating Material for Suture Implant in Rat Skin

Effect of Crescentia cujete (L.) Fruit Extract as a Thread-Coating Material for Suture Implant in Rat Skin
type: AcademicArticle
type: Article
abstract: Thread coatings on suture implants are designed to enhance biocompatibility and biodegradability, supporting wound healing by reducing inflammation and accelerating collagen density. Ascorbic acid, an antioxidant found in specific coatings, can help to increase collagen density. One specific antioxidant is derived from the calabash fruit (Crescentia cujete-Linnaeus). Using a rat model, this study evaluated the effectiveness of calabash fruit extract (CFE) as a suture material for skin implants. The experiment was conducted with 16 female rats, each 12 months old and weighing 300 grams. The rats were randomly divided into four groups, including P1 (control), P2 (cannula), P3 (implanted with polydioxanone), and P4 (implanted with polydioxanone coated with 100% calabash fruit extract). The sutures were implanted on both the left and right sides of the rats' back skin. Skin samples were collected on days 3 and 7 and analyzed for histopathology, collagenization, and the immunoreactivity of interleukin-6 and fibroblast growth factor. Group P4 showed better histopathological score, collagenization, and the percentage of IL-6's immunoreactivity and FGF than the other groups. Histopathological analysis indicated reduced inflammation, smaller intradermal wound diameters, and increased fibroblasts and collagen density in P4 compared to P3 (the group with PDO without CFE coating). Additionally, P4 displayed better IL-6 and FGF immunoreactivity than the other groups. This study demonstrated that CFE can enhance skin quality following suture implantation. The significant benefits of CFE on skin histopathology, collagenization, IL-6, and FGF immunoreactivity offer promise for its potential applications in wound healing.
date: 2025-06-25
volume: 15
issue: 2
is part of: World’s Veterinary Journal
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Effect of Crescentia cujete (L.) Fruit Extract as a Thread-Coating Material for Suture Implant in Rat Skin (Text)
has version: Effect of Crescentia cujete (L.) Fruit Extract as a Thread-Coating Material for Suture Implant in Rat Skin (Text)
has published: Effect of Crescentia cujete (L.) Fruit Extract as a Thread-Coating Material for Suture Implant in Rat Skin (Text)
subject: SF Animal culture

Effect of Crescentia cujete (L.) Fruit Extract as a Thread-Coating Material for Suture Implant in Rat Skin (Text)
type: Document
has file: WVJ15(2)274-282,2025 (1).pdf
has part: WVJ15(2)274-282,2025 (1).pdf

Scienceline Publication
type: Organization

World’s Veterinary Journal
type: Collection
issn: 23224568

Bambang Sutrisno
type: Person
given name: Bambang
family name: Sutrisno

Ria Utami
type: Person
given name: Ria
family name: Utami

Sitarina Widyarini
type: Person
given name: Sitarina
family name: Widyarini

http://eprints.science-line.com/id/eprint/1547/
title: HTML Summary of #1547 <epc:when xmlns:epc="http://eprints.org/ep3/control" test="title">Effect of Crescentia cujete (L.) Fruit Extract as a Thread-Coating Material for Suture Implant in Rat Skin</epc:when>
format: text/html
primary topic: Effect of Crescentia cujete (L.) Fruit Extract as a Thread-Coating Material for Suture Implant in Rat Skin

SF Animal culture
type: Concept