eprintid: 1505
rev_number: 6
eprint_status: archive
userid: 5
source: Scopus
dir: disk0/00/00/15/05
datestamp: 2025-12-26 09:17:16
lastmod: 2025-12-26 09:17:16
status_changed: 2025-12-26 09:17:16
type: article
metadata_visibility: show
creators_name: Zhelavskyi, Mykola
creators_name: Kernychnyi, Serhii
creators_name: Zakharova, Tatiana
creators_name: Betlinska, Tamara
creators_name: Luchkа, Maksym
creators_id: nicoladoctor@gmail.com
title: Canine Mast Cell Tumors: Clinical Signs, Laboratory Diagnosis, Treatment, and Prognosis
ispublished: pub
subjects: SF
divisions: j13
full_text_status: public
keywords: Canine; Diagnosis; Mast cell tumor; Mastocytoma; Skin tumor
abstract: Canine mast cell tumors, a tumor originating from mast cells involved in allergic reactions and inflammation, are among the most common skin tumors in dogs. The present study aimed to explore the clinical features, diagnostic approaches, and prognosis of canine mastocytomas through a case study. A 5-year-old male Akita, weighing 35.8 kg, was brought to the Doctor VET veterinary clinic in Kamianets-Podilskyi, Ukraine, for evaluation. Upon initial examination, the dog had a body temperature of 38.5°C, a heart rate of 74 beats per minute (bpm), and a respiratory rate of 28 breaths per minute, all of which were within normal physiological limits. The animal was alert and responsive and displayed no signs of systemic distress. A detailed physical examination revealed a tumor located 35.2 mm below the plantar surface of the tarsal joint (art. tarsi). The tumor was round, mobile, and surrounded by a thin fibrous capsule, with no signs of pain or discomfort during palpation. Cytological analysis showed a high-cellularity smear with numerous mast cells scattered throughout the field. These cells were round to oval in shape with abundant cytoplasm containing dense, basophilic to metachromatic granules. The hematological evaluation indicated a systemic inflammatory or immune response triggered by the tumor, as evidenced by neutrophilic leukocytosis (73.1; 8.89×109/L). Biochemical analysis revealed an elevated alkaline phosphatase activity level (4.45 μmol/L), suggesting systemic involvement. The tumor was surgically excised, ensuring complete removal with wide margins to minimize the risk of recurrence. Histological examination of the excised tissues confirmed a densely cellular neoplastic infiltrate composed predominantly of mast cells arranged in sheets and clusters. The mast cells displayed significant cellular and nuclear pleomorphism, characterized by moderate to marked anisocytosis and anisokaryosis. While no significant necrosis was observed, scattered apoptotic bodies were present, indicating ongoing cellular turnover. This case highlighted the critical importance of early diagnosis and comprehensive management of canine mastocytomas. Low-grade tumors often carry a favorable prognosis when treated promptly and appropriately. However, higher-grade or poorly differentiated tumors may require multimodal therapeutic approaches to achieve better outcomes. Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/. © The Author(s) 2025
date: 2025-03-25
publication: World's Veterinary Journal
volume: 15
number: 1
publisher: Scienceline Publication
pagerange: 31 -41
id_number: 10.54203/scil.2025.wvj4
refereed: TRUE
issn: 2322-4568
official_url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-105003045740&doi=10.54203%2fscil.2025.wvj4&partnerID=40&md5=95c7bb4a745b817c37239e3cafbcfb75
j_index: scopus
citation:    (2025)     Canine Mast Cell Tumors: Clinical Signs, Laboratory Diagnosis, Treatment, and Prognosis.   World's Veterinary Journal.  31 -41.  ISSN 2322-4568   
document_url: http://eprints.science-line.com/id/eprint/1505/1/WVJ15%281%2931-41%2C%202025%20%281%29.pdf