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primary topic: Canine Mast Cell Tumors: Clinical Signs, Laboratory Diagnosis, Treatment, and Prognosis

Canine Mast Cell Tumors: Clinical Signs, Laboratory Diagnosis, Treatment, and Prognosis
type: AcademicArticle
type: Article
abstract: Canine mast cell tumors, a tumor originating from mast cells involved in allergic reactions and inflammation, are among the most common skin tumors in dogs. The present study aimed to explore the clinical features, diagnostic approaches, and prognosis of canine mastocytomas through a case study. A 5-year-old male Akita, weighing 35.8 kg, was brought to the Doctor VET veterinary clinic in Kamianets-Podilskyi, Ukraine, for evaluation. Upon initial examination, the dog had a body temperature of 38.5°C, a heart rate of 74 beats per minute (bpm), and a respiratory rate of 28 breaths per minute, all of which were within normal physiological limits. The animal was alert and responsive and displayed no signs of systemic distress. A detailed physical examination revealed a tumor located 35.2 mm below the plantar surface of the tarsal joint (art. tarsi). The tumor was round, mobile, and surrounded by a thin fibrous capsule, with no signs of pain or discomfort during palpation. Cytological analysis showed a high-cellularity smear with numerous mast cells scattered throughout the field. These cells were round to oval in shape with abundant cytoplasm containing dense, basophilic to metachromatic granules. The hematological evaluation indicated a systemic inflammatory or immune response triggered by the tumor, as evidenced by neutrophilic leukocytosis (73.1; 8.89×109/L). Biochemical analysis revealed an elevated alkaline phosphatase activity level (4.45 μmol/L), suggesting systemic involvement. The tumor was surgically excised, ensuring complete removal with wide margins to minimize the risk of recurrence. Histological examination of the excised tissues confirmed a densely cellular neoplastic infiltrate composed predominantly of mast cells arranged in sheets and clusters. The mast cells displayed significant cellular and nuclear pleomorphism, characterized by moderate to marked anisocytosis and anisokaryosis. While no significant necrosis was observed, scattered apoptotic bodies …
date: 2025-03-25
volume: 15
issue: 1
is part of: World's Veterinary Journal
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Canine Mast Cell Tumors: Clinical Signs, Laboratory Diagnosis, Treatment, and Prognosis (Text)
has version: Canine Mast Cell Tumors: Clinical Signs, Laboratory Diagnosis, Treatment, and Prognosis (Text)
has published: Canine Mast Cell Tumors: Clinical Signs, Laboratory Diagnosis, Treatment, and Prognosis (Text)
subject: SF Animal culture

Canine Mast Cell Tumors: Clinical Signs, Laboratory Diagnosis, Treatment, and Prognosis (Text)
type: Document
has file: WVJ15(1)31-41, 2025 (1).pdf
has part: WVJ15(1)31-41, 2025 (1).pdf

Scienceline Publication
type: Organization

World's Veterinary Journal
type: Collection
issn: 23224568

Tamara Betlinska
type: Person
given name: Tamara
family name: Betlinska

Tatiana Zakharova
type: Person
given name: Tatiana
family name: Zakharova

Maksym Luchkа
type: Person
given name: Maksym
family name: Luchkа

Mykola Zhelavskyi
type: Person
given name: Mykola
family name: Zhelavskyi

Serhii Kernychnyi
type: Person
given name: Serhii
family name: Kernychnyi

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primary topic: Canine Mast Cell Tumors: Clinical Signs, Laboratory Diagnosis, Treatment, and Prognosis

SF Animal culture
type: Concept