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primary topic: Antibody Responses in Pigs Induced by Inactivated Vaccine Against Streptococcus suis Formulated with Montanide ISA 201 and Montanide Gel 01 Adjuvants

Antibody Responses in Pigs Induced by Inactivated Vaccine Against Streptococcus suis Formulated with Montanide ISA 201 and Montanide Gel 01 Adjuvants
type: AcademicArticle
type: Article
abstract: Streptococcus suis (S. suis) is a zoonotic pathogen responsible for streptococcosis, causing substantial economic losses in swine production worldwide. The present study evaluated the humoral immune response in 8-week-old Landrace pigs immunized with an inactivated autogenous S. suis vaccine formulated with either Montanide™ ISA 201 VG or Gel 01 adjuvants. A completely randomized experimental design assigned 12 male, 8-week-old Landrace male pigs to three groups. The control group received Montanide™ ISA 201 VG adjuvant without antigen (P1), the second group received antigen and Montanide™ ISA 201 VG (P2), and the third group received antigen and Montanide™ Gel 01 (P3). Vaccination was performed by intramuscular injection into the neck muscle using 4 mL of vaccine suspension. Serum samples from all groups were collected weekly for nine weeks post-vaccination, and antibody titers were quantified using an indirect enzyme-linked immunosorbent assay. Clinical parameters, including body temperature, behavioral changes, and weight gain, were monitored weekly for nine weeks. Both adjuvanted vaccine groups (P2 and P3) demonstrated significantly higher antibody titers compared to the control group, with no significant difference between adjuvant types. A progressive increase in antibody levels was observed from week one to week nine in Groups 2 and 3. No vaccine-associated adverse effects were noted. The S.suis vaccine formulated with either Montanide™ ISA 201 VG or Montanide™ Gel 01 adjuvants demonstrated a proper safety profile, with no adverse effects on health or growth performance, and was effective in stimulating strong antibody responses in Landrace pigs. The average antibody titer produced by the vaccine using Montanide™ ISA 201 VG was 0.404 ± 0.201, whereas the vaccine with Montanide™ Gel 01 achieved a titer of 0.404 ± 0.199. The adjuvants elicited comparable immune responses in pigs with no statistically significant difference in antibody titers. The present findin…
date: 2025-06-30
volume: 15
issue: 2
is part of: World's Veterinary Journal
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
subject: SF Animal culture

Scienceline Publication
type: Organization

World's Veterinary Journal
type: Collection
issn: 23224568

Ni Komang Wahyu Centika Sari
type: Person
given name: Ni Komang Wahyu Centika
family name: Sari

I Nengah Kerta Besung
type: Person
given name: I Nengah Kerta
family name: Besung

I Gede Bagas Upaditha Adresya Kaler
type: Person
given name: I Gede Bagas Upaditha Adresya
family name: Kaler

Ni Ketut Suwiti
type: Person
given name: Ni Ketut
family name: Suwiti

I Gusti Ngurah Kade Mahardika
type: Person
given name: I Gusti Ngurah Kade
family name: Mahardika

http://eprints.science-line.com/id/eprint/1465/
title: HTML Summary of #1465 <epc:when xmlns:epc="http://eprints.org/ep3/control" test="title">Antibody Responses in Pigs Induced by Inactivated Vaccine Against Streptococcus suis Formulated with Montanide ISA 201 and Montanide Gel 01 Adjuvants</epc:when>
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primary topic: Antibody Responses in Pigs Induced by Inactivated Vaccine Against Streptococcus suis Formulated with Montanide ISA 201 and Montanide Gel 01 Adjuvants

SF Animal culture
type: Concept