TY  - JOUR
VL  - 14
Y1  - 2024/12/25/
KW  - Chicken
KW  -  Hematology
KW  -  Itraconazole
KW  -  LD50
KW  -  Liver
KW  -  Mice
IS  - 4
AV  - public
N2  - Itraconazole is a systemic antifungal often used for fungal infection treatment in cats. This study aimed to evaluate the safety of chicken liver paste as a drug filler through an acute toxicity test when supplemented with itraconazole. A total of 25 female mice were used and divided into five groups, each consisting of five mice. The control group received chicken liver paste without any itraconazole supplementation. In contrast, the treatment groups were administered chicken liver paste supplemented with itraconazole at 5, 10, 15, and 20 g/kg body weight dosages. Observations were conducted for two weeks. The evaluated parameters included abnormal clinical signs, mortality, body temperature, weight gain, and hematology profile. During the 14 days of observation, no mortality or abnormal clinical signs were observed. Other parameters such as body temperature and weight increase showed no significant difference. Hematology profile including red blood cells (RBC), hemoglobin (HB), hematocrit (Hct), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), red cell distribution width (RDW), thrombocyte (PLT), mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), white blood cells (WBC), lymphocytes, monocytes, and granulocytes remained within the standard ranges and showed no significant difference. The present study indicated that chicken liver paste supplemented with itraconazole falls into the practically nontoxic category with an estimated LD50 value exceeding 20 g/kg body weight.
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85214389317&doi=10.54203%2fscil.2024.wvj66&partnerID=40&md5=584ef84195d0502e1cfa066aef0793f7
EP  - 591
JF  - World's Veterinary Journal
TI  - The Toxicity Assessment of Chicken Liver-Based Drug Filler Supplemented with Itraconazole
SP  - 584 
PB  - Scienceline Publication
SN  - 2322-4568
ID  - eprints1344
A1  - Pringgodigdoyo, Prapatantio Teteg
A1  - Manalu, Wasmen
A1  - Andriyanto, .
A1  - Mustika, Aulia Andi
A1  - Sutardi, Lina Noviyanti
ER  -