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primary topic: The Toxicity Assessment of Chicken Liver-Based Drug Filler Supplemented with Itraconazole

The Toxicity Assessment of Chicken Liver-Based Drug Filler Supplemented with Itraconazole
type: AcademicArticle
type: Article
abstract: Itraconazole is a systemic antifungal often used for fungal infection treatment in cats. This study aimed to evaluate the safety of chicken liver paste as a drug filler through an acute toxicity test when supplemented with itraconazole. A total of 25 female mice were used and divided into five groups, each consisting of five mice. The control group received chicken liver paste without any itraconazole supplementation. In contrast, the treatment groups were administered chicken liver paste supplemented with itraconazole at 5, 10, 15, and 20 g/kg body weight dosages. Observations were conducted for two weeks. The evaluated parameters included abnormal clinical signs, mortality, body temperature, weight gain, and hematology profile. During the 14 days of observation, no mortality or abnormal clinical signs were observed. Other parameters such as body temperature and weight increase showed no significant difference. Hematology profile including red blood cells (RBC), hemoglobin (HB), hematocrit (Hct), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), red cell distribution width (RDW), thrombocyte (PLT), mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), white blood cells (WBC), lymphocytes, monocytes, and granulocytes remained within the standard ranges and showed no significant difference. The present study indicated that chicken liver paste supplemented with itraconazole falls into the practically nontoxic category with an estimated LD50 value exceeding 20 g/kg body weight.
date: 2024-12-25
volume: 14
issue: 4
is part of: World's Veterinary Journal
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: The Toxicity Assessment of Chicken Liver-Based Drug Filler Supplemented with Itraconazole (Text)
has version: The Toxicity Assessment of Chicken Liver-Based Drug Filler Supplemented with Itraconazole (Text)
has published: The Toxicity Assessment of Chicken Liver-Based Drug Filler Supplemented with Itraconazole (Text)
subject: SF Animal culture

The Toxicity Assessment of Chicken Liver-Based Drug Filler Supplemented with Itraconazole (Text)
type: Document
has file: WVJ14(4) 584-591, 2024 (2).pdf
has part: WVJ14(4) 584-591, 2024 (2).pdf

Scienceline Publication
type: Organization

World's Veterinary Journal
type: Collection
issn: 23224568

Lina Noviyanti Sutardi
type: Person
given name: Lina Noviyanti
family name: Sutardi

Wasmen Manalu
type: Person
given name: Wasmen
family name: Manalu

Aulia Andi Mustika
type: Person
given name: Aulia Andi
family name: Mustika

Prapatantio Teteg Pringgodigdoyo
type: Person
given name: Prapatantio Teteg
family name: Pringgodigdoyo

. Andriyanto
type: Person
given name: .
family name: Andriyanto

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primary topic: The Toxicity Assessment of Chicken Liver-Based Drug Filler Supplemented with Itraconazole

SF Animal culture
type: Concept