eprintid: 1342
rev_number: 7
eprint_status: archive
userid: 5
source: Scopus
dir: disk0/00/00/13/42
datestamp: 2025-12-26 09:05:42
lastmod: 2025-12-26 09:05:42
status_changed: 2025-12-26 09:05:42
type: article
metadata_visibility: show
creators_name: Krestonoshina, Kseniya
creators_name: Melnichuk, Anastasia
creators_id: melnichukad1999@gmail.com
title: Contribution of Cytochrome P450s to Development of Insecticide Resistance in Musca domestica L.: A Review
ispublished: pub
subjects: SF
divisions: j13
full_text_status: public
keywords: Gene expression, Housefly, Insecticide, Insecticidal resistance, Monooxygenase, Сytochromes P450
abstract: Musca domestica L. (Diptera: Muscidae) is recognized as one of the most prevalent fly species globally, playing a significant role in the transmission of infections and pathogens that are important in both veterinary and medical contexts. This includes the dissemination of eggs from intestinal helminths, as well as ectoparasites, endoparasites, and protozoan cysts. Several approaches to combating insect pests include biological, physical, chemical, and agrotechnical methods. Chemical methods remain the main strategy for controlling the population of insect pests; however, excessive use, increased dosages, and frequency of treatments have led to the development of resistance. To date, numerous documented cases of resistance to insecticides have been registered in natural populations. A significant mechanism for resistance development is the detoxification of xenobiotics by enzymes of the cytochrome system. This study aimed to summarize the current knowledge on the role of P450 monooxygenase in developing insecticide resistance in houseflies. This overview focuses on the diversity of Cytochrome P450 monooxygenases in Musca domestica that contribute to resistance against the most popular classes of insecticides and their location in the genome. Throughout this work, the main P450 candidate genes associated with insecticide resistance were identified and described. The authors also summarized and systematized recent research results in this area.
date: 2024-12-25
publication: World's Veterinary Journal
volume: 14
number: 4
publisher: Scienceline Publication
pagerange: 652-658
id_number: 10.54203/scil.2024.wvj74
refereed: TRUE
issn: 2322-4568
official_url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85214379372&doi=10.54203%2fscil.2024.wvj74&partnerID=40&md5=e4fafd663f3c6351a016f4532628c365
j_index: scopus
citation:    (2024)     Contribution of Cytochrome P450s to Development of Insecticide Resistance in Musca domestica L.: A Review.   World's Veterinary Journal.  pp. 652-658.  ISSN 2322-4568   
document_url: http://eprints.science-line.com/id/eprint/1342/1/WVJ14%284%29%20652-658%2C%202024%20%282%29.pdf