@article{eprints1243,
           pages = {349--354},
           title = {The Pharmacokinetics of Ceftazidime Following its Intravenous Administration in Dogs},
          number = {3},
           month = {September},
          volume = {14},
       publisher = {SCIENCELINE},
          author = {Al-Jumaili Mustafa A. and Al-Abbass Nibras N. and S. Ibrahim Orooba M.},
            year = {2024},
         journal = {World's Veterinary Journal},
        abstract = {Ceftazidime is a beta-lactam that is used in the treatment of bacterial infections in humans and companion animals, such as dogs and cats. It is prescribed to treat gram-negative infections, especially those caused by Pseudomonas aeruginosa. This study aimed to compare the pharmacokinetics of ceftazidime using a microbiological assay to evaluate the adequacy of the proposed dosage regimens for susceptible gram-negative bacteria. For this purpose, five healthy mongrel male dogs, with a mean age of four years and an average weight of 19.1 kg, were administered a single intravenous bolus dose of ceftazidime (20 mg/kg). Plasma concentrations were measured using a microbiological assay, and dosage regimens were established by integrating pharmacokinetics data with pharmacodynamics parameters. The results showed that ceftazidime was rapidly distributed to the peripheral tissues (0.189 L/kg), with a half-life of 1.15 hours and a clearance rate of 0.166 L/hr./kg. The results obtained from the pharmacokinetics-pharmacodynamic integration suggested 20 mg/kg q8 hours of ceftazidime for susceptible gram-negative bacteria with a Minimum Inhibitory Concentration of {$\leq$} 8 ?g/ml, and 20 mg /kg q12 hours of ceftazidime for susceptible gram-negative bacteria with a Minimum Inhibitory Concentration of {$\leq$} 4 ?g/ml. In conclusion, a mild correlation was observed between the dogs? weight and the ceftazidime half-life, which led to an adjustment of the proposed dosage regimen to 20 mg/kg q8 hours.},
        keywords = {Ceftazidime, Dog, Dosage regimen, Gram-negative microbe, Pharmacokinetic},
             url = {http://eprints.science-line.com/id/eprint/1243/}
}