TY  - JOUR
KW  - C reactive protein; cisplatin; colecalciferol; interleukin 12; tumor necrosis factor
KW  -  adult; animal experiment; animal model; Article; controlled study; dose response; drug dose comparison; drug effect; eosinophil percentage; immune deficiency; immunological parameters; leukocyte count; lymphocyte percentage; male; monocyte percentage; neutrophil percentage; nonhuman; platelet count; protein blood level; rat; vitamin supplementation
TI  - The Effects of Different Concentrations of Vitamin D3 on Immunological Parameters of Immunosuppressed Rats Induced
ID  - eprints1208
JF  - World's Veterinary Journal
AV  - public
SP  - 145
VL  - 14
N2  - Vitamin D3 receptor is expressed in several types of immune cells suggesting that Vitamin D3 could have immune regulatory roles. The current study was conducted to investigate the role of Vitamin D3 in reducing the toxicity of the cisplatin on some Immunological parameters in the rat model. The current experiment was conducted on 80 adult white male rats within the age range of 9-12 weeks. The animals were divided into eight groups (10 animals in each group). The control group was dosed with the physiological solution until the end of experiment (C). Rats in the second treatment were injected with cisplatin (2 mg/kg, T1). Rats in the third (T2), fourth (T3), and fifth (T4) groups were injected with cisplatin at a concentration (2 mg/kg) and received Vitamin D3 at levels of 5000 IU, 10,000 IU, and 15,000 IU, respectively. The rats in the sixth (T5), seventh (T6), and eighth (T7) groups were subjected to Vitamin D3 at concentrations of 5000 IU,10,000 IU, and 15,000 IU, respectively. At the end of the experiment, which lasted 21 days, the animals were anesthetized, their weights were recorded, and blood samples were collected. The findings revealed a significant elevation in the levels of interleukin-12, tumor necrosis factor-alpha, C-reactive protein, lymphocyte percentage, monocyte percentage, and eosinophil percentage within group T1 compared to the control and other treatment groups that received Vitamin D3. The average percentage of white blood cells and neutrophils in group T1 was significantly lesser than other groups. It can be concluded that supplementation of different Vitamin D3 levels (5000-10,000 IU) have positive influences on the immunological parameters of immunosuppressed rats. © (2024) Baishideng Publishing Group Inc. All rights reserved.
EP  - 150
SN  - 23224568
IS  - 1
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85193366088&doi=10.54203%2fSCIL.2024.WVJ18&partnerID=40&md5=8979891d25fb6836edd62578b66a6eb0
PB  - Scienceline Publication
N1  - Department Biology, College of Education, University of Al-Qadisiyah, Iraq
A1  - Kmosh, S.M.
A1  - Al-Naely, A.J.
Y1  - 2024/03/30/
ER  -