eprintid: 1183
rev_number: 7
eprint_status: archive
userid: 5
source: Scopus
dir: disk0/00/00/11/83
datestamp: 2025-02-08 03:53:26
lastmod: 2025-02-08 03:53:26
status_changed: 2025-02-08 03:53:26
type: article
metadata_visibility: show
creators_name: Sedegan, E.B.F.
creators_name: Akpo, Y.
creators_name: Boko, K.C.
creators_name: Azalou, M.
creators_name: Adoligbé, C.
creators_name: Iwaka, C.
creators_name: Attakpa, E.
creators_name: Traoré, I.A.
title: The Effects of Acute Oral Toxicity of Jatropha multifida and Hyptis suaveolens on Zootechnical Parameters in Local Chickens
ispublished: pub
subjects: SF
divisions: j13
full_text_status: public
keywords: alcohol; distilled water; Hyptis suaveolens extract; Jatropha multifida extract; plant extract; unclassified drug; water, acute oral toxicity; acute toxicity; agricultural parameters; animal experiment; Article; body weight; chicken breed; controlled study; drug safety; fluid intake; food intake; Gallus gallus; Hyptis; Hyptis suaveolens; LD50; mortality; nonhuman; phytochemistry; productivity; suspension; toxicity testing; zootechnical parameters
note: Laboratoire d’Ecologie, de Santé et de Production Animales (LESPA), Université de Parakou, 01, Parakou, 123, Benin; Unité de Recherches sur les Maladies Transmissibles (URMAT), Université d’Abomey-Calavi, Bénin, Enseignent chercheur à l’Ecole Polytechnique de l’Université d’Abomey-calavi, 01BP 2009, Cotonou, Benin
abstract: The substantial use of medicinal plants in traditional poultry farming is a well-established practice. The present study aimed to determine the median lethal dose (LD50) of ethanolic extracts of Jatropha multifida and Hyptis suaveolens in local chickens and to assess the effects of these extracts on feed intake, water intake, and average body weight. The methodology followed OECD Directive 223, which involves administering the highest dose of the extract to the chickens and assessing any mortality. Three homogeneous groups of five chickens each were formed for the limit dose test. The control group received distilled water, while batches 1 and 2 received 700 mg of ethanolic extract of J. multifida and H. suaveolens, respectively. The average body weight of the chickens was 350g ± 20, and the extracts were administered via gavage at a suspension of 2000 mg/kg.bwt of the extract dissolved in water. The results of the phytochemical tests indicated the presence of several chemical compounds known for their therapeutic effects. The productivity of the extract was 2.75 ± 0.19 for J. multifida and 3.3 ± 0.27 for H. suaveolens. After administration of the suspensions, observation for 14 days revealed no mortality. This finding indicated that the LD50 of the utilized ethanolic extracts exceeds the limit dose (2000 mg/kg.bwt). However, feed intake (49 ± 3 > 46±4) and average body weight (436 ± 31 > 388 ± 37) in batch 2 were significantly higher than those in batch 1. Future research should explore the subacute toxicity of J. multifida and H. suaveolens across various chicken breeds. Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/. © The Author(s) 2024
date: 2024-09-25
publication: World's Veterinary Journal
volume: 14
number: 3
publisher: Scienceline Publication
pagerange: 328-337
id_number: 10.54203/scil.2024.wvj39
refereed: TRUE
issn: 23224568
official_url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85206315175&doi=10.54203%2fscil.2024.wvj39&partnerID=40&md5=10cdd786127bb61614b98ca6c366e9f8
j_index: scopus
citation:    (2024)     The Effects of Acute Oral Toxicity of Jatropha multifida and Hyptis suaveolens on Zootechnical Parameters in Local Chickens.   World's Veterinary Journal.  pp. 328-337.  ISSN 23224568   
document_url: http://eprints.science-line.com/id/eprint/1183/1/WVJ%2014%283%29%20328-337%2C%202024.pdf